Ketoprofen in the treatment of acute and chronic pain: review of literature data


Characteristics of Ketorol

Ketorol belongs to the group of NSAIDs. The active ingredient is ketorolac. It has several dosage forms - film-coated tablets, solution for intramuscular and intravenous injections, gel for external use. It has analgesic, antipyretic and anti-inflammatory effects.

Ketorol is used to relieve acute pain, the cause and location of which may be different, including:

  • periods after various medical procedures - orthopedic, gynecological, laparoscopic;
  • injuries and burns;
  • migraine, toothache;
  • renal and hepatic colic;
  • pain symptoms in sickle cell anemia;
  • neuralgia, neuritis, pain syndrome with herpes zoster.

The drug is not used in the treatment of chronic pain.

Ketorol is contraindicated in case of individual intolerance to the substances included in its composition. The medicine is not prescribed for aspirin-induced asthma, peptic ulcer of the gastrointestinal tract, kidney disease, hemostasis, hemorrhagic stroke, congestive heart failure. This painkiller should not be used in the treatment of children and adolescents under 16 years of age.

If medical recommendations are not followed, side effects may develop, which are manifested by pain in the abdomen, dyspeptic symptoms, drowsiness, emotional anxiety, and allergies.


These drugs are considered the most powerful medications that can fight not only pain, but also inflammation and fever.

Most common side effects

As mentioned above, the painkillers in question have more in common than they are common, so the list of potential side effects here will be approximately the same. Here are the most common negative reactions that the body can give to the effects of ketorolac:

  • problems in the gastrointestinal tract,
  • fast fatiguability,
  • headache, dizziness,
  • sudden weight gain,
  • swelling of the limbs and face,
  • increased sweating.


One of the side effects may be a gastrointestinal problem.
This is not a complete list of possible side effects and not the most serious of them. In some situations, the patient may experience severe stomach pain and vomiting. Sometimes there is a sharp increase in blood pressure, which is accompanied by hearing loss and severe shortness of breath. Manifestations of allergic rhinitis and urticaria may also occur. An overdose can lead to vomiting, drowsiness, hallucinations and severe poisoning with subsequent stomach ulcers.

Characteristics of Ketanov

The active component of the drug is ketorolac. Available in the form of tablets and solution for injection. A strong analgesic effect is the main therapeutic property of the drug. It also fights inflammation and relieves fever.

Ketanov is considered the most powerful pain reliever among the drugs included in the NSAID group. Effectively combating pain of various origins, the drug is not a narcotic drug, i.e. it is not addictive.

Ketanov is used if it is necessary to quickly relieve pain of any location and origin:

  • after operations and injuries;
  • dental, muscle and postpartum pain;
  • drug withdrawal;
  • after dental procedures;
  • renal or biliary colic;
  • tumors;
  • osteoarthritis, osteoarthritis, osteochondrosis;
  • inflammation of the sciatic nerve.

We recommend reading: What is the difference between Ketonal and Ketonal Duo?
The drug has many contraindications for use:

  • exacerbation of gastrointestinal ulcers;
  • hemophilia and hypocoagulation;
  • hemorrhagic stroke and diathesis;
  • angioedema;
  • aspirin asthma;
  • spasms in the bronchi;
  • chronic pain;
  • pregnancy and lactation;
  • age up to 16 years;
  • intolerance to the components of the drug.

You should not take Ketanov without a doctor's prescription. This is a strong remedy and not recommended for everyday use.


You should not take Ketanov without a doctor’s prescription; it is a strong remedy and not recommended for everyday use.

Description of "Ketanova"

The main active ingredient of the drug is ketorolac. It comes in the form of tablets for internal use and intramuscular solution. It has a strong analgesic effect. In addition, it relieves inflammation and normalizes temperature.

Among similar medications in the NSAID group, Ketanov is the most powerful. Quickly eliminates even severe pain, but does not contain narcotic substances.

Ketanov should be used to quickly block pain:

  • – after surgery;
  • – injuries of various origins;
  • – postpartum pain;
  • – tooth and muscle pain;
  • – during drug withdrawal;
  • – after dental procedures;
  • – colic of the kidneys or gall bladder;
  • – tumor;
  • – joint pathologies;
  • – with an inflammatory process in the sciatic nerve.

The medicine has many limitations:

  • – stomach ulcer;
  • – hemophilia;
  • – hypocoagulation;
  • – diathesis;
  • - stroke;
  • – bronchospasm;
  • – angioedema;
  • – asthma;
  • – period of gestation;
  • - lactation;
  • – chronic pain syndrome;
  • – children under 16 years of age;
  • – individual intolerance to substances.

It is not recommended to take Ketanov without a doctor's prescription. The medication is very strong, so it is not suitable for daily use.

Before using a pain reliever, you should definitely consult a specialist. Taking such strong drugs on your own can cause unforeseen complications.

Comparison of Ketorol and Ketanov

The drugs have both similarities and differences.

Similarities

Both drugs contain the same active ingredient, the same indications for use and contraindications. Ketanov and Ketorol belong to the same pharmacological group of non-steroidal anti-inflammatory drugs.

Both medications have the same release forms - for oral administration, injection and external use.

What is the difference?

Despite the great similarity, the drugs still differ from each other, for example by their manufacturers. Ketanov is produced by the Indian company S.K.Therapy S.A., and Ketorol is produced by another Indian company Dr. Reddy S Laboratories.

Which is stronger and more effective?

Ketanov is a stronger remedy. It is recommended to take it for complex injuries and burns. Under the influence of Ketorol, platelets stick together, so this medicine is considered more effective for wound healing.

When choosing a drug, you should also take into account contraindications, so you should carefully read the instructions. Ketanov has more of them.

Ketorol is less dangerous during pregnancy and breastfeeding. But you still shouldn’t use it without consulting a doctor.


Ketorol is less dangerous during pregnancy and breastfeeding, but you should still not use it without consulting a doctor.

Which is cheaper?

Ketorol price:

  • tablets - from 40 rubles;
  • solution - from 130 rubles;
  • gel – from 230 rub.

Ketanov price:

  • tablets - from 50 rubles;
  • solution - from 100 rubles;
  • gel – from 340 rub.;
  • cream – from 310 rub.

Conditions for dispensing from pharmacies

Both drugs, available in gel or cream form, are over-the-counter products, and tablets and ampoules are available with a doctor's prescription.

We recommend reading: What to choose: Don powder or tablets?

When are these painkillers contraindicated?

Before taking the Ketanova or Ketorola tablet, you must consult your doctor and carefully read the instructions for use. The medications in question have quite a few contraindications, and therefore it is strongly not recommended to take them without prior examination. Thus, experts consider the following phenomena and conditions to be the main limiting factors:

  • allergy or intolerance to even one component included in the product,
  • peptic ulcer of the stomach and duodenum,
  • intestinal inflammation,
  • problems with blood clotting,
  • pathological conditions of the liver and kidneys,
  • disruptions in the functioning of the heart and blood vessels,
  • internal bleeding of various etiologies,
  • disruptions in the digestive system,
  • pregnancy, breastfeeding,
  • children's age (up to 16 years).


During pregnancy, the use of these drugs is contraindicated.
The doctor can also significantly reduce the dosage if the patient is diagnosed with certain pathological conditions. For example, the drug can be taken in minimal doses for vegetative-vascular dystonia, diabetes mellitus, viral hepatitis, high blood pressure and alcoholism.

Important! During pregnancy, as well as while the mother is breastfeeding, taking Ketanov and Ketorol is contraindicated. Regarding whether it is possible to give tablets to children, here it is worth limiting yourself to even less strong, but at the same time safer drugs, and it is better to consult with your pediatrician on this matter. These painkillers are approved for children over 16 years of age. Only in rare cases can they be prescribed to a child over 2 years old.

Limitations in dosages directly depend on the characteristics of the body of each individual patient. In addition, it is worth taking into account that these drugs are indicated for use to relieve acute symptoms, and they are practically not used in the treatment of chronic pain.

Which is better: Ketorol or Ketanov?

Even a doctor cannot accurately answer this question. When prescribing, many factors are taken into account, including the patient’s health status. It is not recommended to choose a medicine on your own.

For osteochondrosis

Ketorol has good anti-inflammatory properties. It copes with inflammation and pain quickly, so doctors often recommend it for osteochondrosis. But the contraindications of the drug should be taken into account. It is not suitable for some patients. Although the medicine is a better pain reliever, it is replaced with less effective medications.

For toothache

For toothache, Ketanov is considered a more suitable remedy. This is especially true for those patients who have had a diseased wisdom tooth removed, since their roots penetrate deep into the jaw. After removal, wounds remain that take a long time to heal, so the doctor recommends painkillers.

It is better to consult a doctor about what doses to take the medication.

What are the differences?

"Ketanov" is produced in two main forms: tablets and as a solution for injection into the muscle. Ketorol is also available in these forms, but is also supplied in gel form. Both products are manufactured in India, but by different manufacturing companies.

As for the visual differences, you can highlight the markings - “KVT” is indicated on the “Ketanov” tablets, and the letter “S” is indicated on “Ketorol”. The products contain identical auxiliary components, except for a few. So, for example, Ketanov contains titanium dioxide, hypromellose and macrogol 400, but Ketorol contains silicon dioxide instead of these components.

According to the results of clinical studies, “Ketanov” is more effectively and quickly absorbed by the body than “Ketorol”. However, the latter has fewer potential side effects in its instructions1. Both drugs have identical indications for use. The differences between them are very conditional, and they need to be taken into account only in situations where the patient has an intolerance to individual components. Why this or that remedy does not help with toothache also largely depends on the individual characteristics of each patient’s body, and to get a detailed answer to this question it is better to consult with your doctor.

Here are the main differences between Ketanov and Ketorol:

  • slight differences in composition,
  • different printing on tablets,
  • “Ketanov” is absorbed by the body more quickly and efficiently,
  • Ketorol has fewer potential side effects (according to the instructions).

Describing the differences between these two drugs, one cannot help but say a few words about their cost. Thus, a package of Ketorol (20 tablets) costs approximately 45 to 60 rubles. A similar package of Ketanov will cost approximately 25% more.

Patient reviews

Yulia, 27 years old, Nizhny Novgorod: “I met Ketorol just a year ago. A friend advised me to take a pill when I had a toothache. Since then I have kept this medicine in my home medicine cabinet. I try not to overuse it. And recently I had such a headache that I had to take the pill again. Helped almost immediately. I recommend".

Leonid, 61 years old, Krasnoyarsk: “My daughter brought Ketanov about six months ago, when he complained to her of severe pain in his knees. The drug helps well, but my daughter warned me not to use it too often. I only take pills when the pain is unbearable.”

Comparison of the effectiveness of Ketanov and Ketorolac

The effectiveness of Ketanov is quite similar to Ketorolac - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Ketanov is more pronounced, then using Ketorolac even in large doses will not achieve this effect.

Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Ketanov and Ketorolac. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.

Reviews from doctors about Ketorol and Ketanov

Igor, 40 years old, neurologist, Samara: “Ketorol is an effective pain reliever that can quickly eliminate pain in inflammatory joint pathologies. But I prescribe it for a short period of time, only at the beginning of the development of the disease, in order to alleviate the patient’s condition.

The drug has many contraindications that should be taken into account. But the medicine has a great advantage - several forms of release make it possible to take the medicine internally, give injections and apply externally.”

We recommend reading: Chondroxide - treatment and prevention of osteoarthritis and osteochondrosis of the spine

Olga, 48 years old, dentist, Khabarovsk: “For severe pain that occurs after the removal of a wisdom tooth, I prescribe Ketanov. The tablets quickly relieve pain. I warn patients that they should not take this medicine often or for a long time, as unpleasant consequences are possible. The medication has many contraindications and side effects are possible.”

Reviews

What do patients say about the drugs?

Lyudmila, 31 years old, Sochi

About a year ago I learned about Ketorol. I had a toothache, and a friend recommended this drug to me. Since then, these tablets have always been in my medicine cabinet. It also helps very well with headaches. However, it is better not to abuse this remedy.

Dmitry, 59 years old, Krasnoyarsk

My knee joints hurt badly. My daughter brought me “Ketanov”. The pain went away almost instantly, but my daughter warned me not to take the pills often. In this regard, I take the medicine only when the pain is unbearable. I recommend.

What do doctors say about the drugs? Doctors' opinion

Nikolai Ivanovich, 46 years old, neurologist, Irkutsk

For joint inflammation, I consider Ketorol to be the most effective remedy. It relieves inflammation and quickly eliminates pain. I prescribe only in the initial stages of the disease. This helps patients alleviate their condition. Tablets have a long list of restrictions. However, the benefits outweigh them. Available in several pharmacological forms. You can take tablets, give injections or use externally.

Irina Vladimirovna, 53 years old, dentist, Vologda

I prescribe Ketanov after surgery to remove a wisdom tooth. The drug relieves pain well. However, it is often impossible to take the medication. Otherwise, unforeseen complications may arise. The medicine may cause adverse reactions. Large list of restrictions.

Tell everyone:

Comparison of safety of Ketanov and Ketorolac

The safety of a drug includes many factors.

At the same time, in Ketanov it is quite similar to Ketorolac. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing metabolism in Ketanov, as well as in Ketorolac, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Ketanov does not have any risks when used, just like Ketorolac.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of the use of Ketanov and Ketorolac.

Rating
( 2 ratings, average 4.5 out of 5 )
Did you like the article? Share with friends:
For any suggestions regarding the site: [email protected]
Для любых предложений по сайту: [email protected]