The drug Nise, its effectiveness and danger for toothache

Does Nise help with toothache?

Nise helps with toothache. Pharmacological properties and patient reviews give grounds to declare the effectiveness of the drug in dentistry, which is taken for the purpose of pain relief. Pain is often caused by an inflammatory process that develops in the pulp and periodontium.

The active ingredient Naiza has the ability to block the attack and development of the inflammation process. Therefore, the remedy is recommended for the manifestation of painful sensations of a different nature, in particular in the tooth.

Benefits of Nise for toothache

• begins to act within 15-30 minutes;
• peak effectiveness is observed after 3 hours;
• the duration of action lasts for 6-12 hours, which allows you to forget about pain for the whole working day;
• in many pharmacies the drug is sold without a prescription, although this is prohibited due to many side effects;
• the active substance is nimesulide, which is prescribed even to pregnant women and children;
• Based on reviews, we can conclude that the product is well tolerated by most patients, even with long-term use;
• the price of a package of 20 tablets in Russia is approximately 150 rubles (7.5 rubles per tablet);
• the product combines well with most painkillers;
• the drug can be taken together with broad-spectrum antibiotics, antihistamines and anti-inflammatory drugs.

Despite the effectiveness and availability of the drug, it has a number of disadvantages, which often force doctors to prescribe other medications to patients for toothache.

Composition and principle of action

Nise in tablet form

The main active component of the drug, which directly blocks pain, is nimesulide. In addition to it, the composition includes auxiliary substances:

• sorbitol;
• aspartame;
• silicon dioxide;
• microcrystalline cellulose;
• talc;
• fruit flavoring, etc.

Nise is available in different forms. For toothache, it is recommended to take tablets and suspensions. For pain relief and relief of inflammation in joints, ligaments and muscles, the drug in the form of an ointment or gel is suitable.

The principle of operation is based on the penetration of active substances into the blood, after which the synthesis of prostaglandins is suppressed at the site of inflammation. Nimesulide, in combination with excipients, selectively inhibits cyclooxygenases, which actually dulls pain. At the same time, the drug does not change hemostasis, that is, the blood retains both its liquid state and its previous chemical composition.

Nise has anti-inflammatory, antipyretic and analgesic effects. The main metabolic product (active hydroxynimesulide) does not accumulate in the body with long-term use and is excreted naturally through the kidneys.

Analogues of Nise for toothache

There are many similar painkillers. The advantage of Nise is due to its high efficiency and availability. This is why the drug is purchased more often than its safe analogues.

Paracetal and drugs based on it, which have become entrenched in the minds of many as antipyretics, have almost the same effect as Nise. At the same time, Paracetal is safer for adults, and especially for children.

Nurofen also has a similar effect to Nise, although the latter still copes better with the inflammatory process. Analgin, banned in many countries due to its ability to cause agranulocytosis (decrease in the level of leukocytes, disruption of the body's barrier function), is not much weaker than Nise.

Popular analogues of Nise

1. Nimesulide is a non-steroidal anti-inflammatory drug of the sulfanilide class. It has an antipyretic, anti-inflammatory, analgesic effect. Through activation of glucocorticosteroid receptors, the anti-inflammatory effect is enhanced. Compared to other drugs, Nimesulide has fewer side effects.
2. Nimulide is a non-steroidal anti-inflammatory drug with the active substance nimesulide, a member of the sulfananilide group. It has an analgesic, antioxidant, anti-inflammatory effect.
3. Ameolin is a drug that has anti-inflammatory, antipyretic, analgesic and antiplatelet effects. The active substance is nimesulide.
4. Nimegesin is an analgesic drug, also based on nimesulide. It has anti-inflammatory, antipyretic, analgesic properties.

Analogues with paracetamol

1. Paracetamol is an antipyretic drug that also has an analgesic and mild anti-inflammatory effect.
2. Strimol is a drug from the analgesic-antipyretic group. Active substances inhibit the synthesis of prostaglandins and affect thermoregulation through the hypothalamus. Strimol has analgesic, antipyretic and mild anti-inflammatory properties.
3. Efferalgan is a drug with pronounced antipyretic and analgesic effects, and also has an antipyretic effect.
4. Sanidol is a drug that has antipyretic and analgesic properties.

Analogs based on analgin

1. Analgin is an analgesic, antipyretic and anti-inflammatory drug. The drug is contraindicated for bronchospasm and hematopoietic disorders. Side effects include: inhibition of hematopoiesis, allergies, anaphylactic shock.
2. Maxigan is a combined remedy designed to relieve pain, eliminate spasms and inflammation. The active substance in the form of the non-narcotic analgesic metamizole sodium, a pyrazolone derivative, promotes analgesia and anti-inflammatory activity.

Analogues based on ibuprofen

1. Nurofen is a non-steroidal anti-inflammatory drug that has an analgesic and mild antipyretic effect. There is an opinion that Nurofen helps in stimulating endogenous interferon, through which it affects the immune system and strengthens the body's protective functions.
2. Ibupron is an anti-inflammatory and antipyretic drug that affects the site of inflammation through the biosynthesis of prostaglandins (inhibition of the cyclooxygenase enzyme).

Analogues based on ketorolac

1. Ketanov is an analgesic and anti-inflammatory drug. In comparison with narcotic analgesics, Ketanov does not depress respiratory function, does not affect the heart muscles, and does not provoke hemodynamic disturbances. Ketanov does not change psychomotor functions.
2. Ketorolac is a non-steroidal anti-inflammatory drug that provides a pronounced analgesic effect. The strength of the drug is comparable to morphine, surpassing other NSAIDs. However, the drug has many contraindications and side effects.

No matter how effective the drug is, if you have a toothache, you need to contact your dentist promptly. Almost always, when teeth are damaged, drug treatment is ineffective. Painkillers are needed only to relieve discomfort for the period necessary to visit a doctor. Other analogues: Mesilid, Prolid, Aponil, Nimika, Flolid, Nimesil, Aktasulide, Kokstral.

Instructions for use

Nise in suspension form

Before taking the drug, you must read the instructions. This will prevent side effects from increasing the dosage or not following health restrictions.

Teenagers over 12 years of age and adults can use Nise in tablets . The daily dose involves taking the drug 2-3 times (after meals), 1 piece each, washed down with clean water (150-200 ml).

For severe pain, the dosage is increased to 4 tablets, but it should not exceed 200 mg for adults and 100-150 mg for children. It is recommended to maintain equal intervals between the use of pain medication (at least 3-4 hours).

The dispersible form of the drug is absorbed better by the body, so the effect occurs in a shorter period of time. This product is dissolved in the amount of 1 teaspoon per glass of water.

A more convenient form of release for children under 12 years of age is Nise in suspension . For 1 kg of a child’s weight, 5 mg of medication is needed. The dose obtained by multiplication is divided into 2-4 doses during the day.

The drug, regardless of the form of release, should be taken for no more than 10 days. During this time, you need to set aside time to visit the dentist in order to determine the diagnosis and begin treatment.

Rules of application

1. The drug is recommended to be used after meals to reduce the toxic effects on the stomach, intestines, liver and kidneys.
2. Tablets are used from 12 years of age, suspension - from 2 years.
3. The drug is taken 1 tablet, twice a day.
4. If the tablets are soluble, then place them in 5 ml of water (a teaspoon) and drink.
5. The daily dosage for adults should not be exceeded - 400 mg of nimesulide.
6. For children, it is recommended to calculate the dosage based on body weight: 3-5 mg per kg of body weight, divided into 2-3 doses.
7. The maximum duration of use is 10 days.
8. If possible, the minimum effective dose of the drug should be taken.

The minimum duration of the analgesic effect is 4 hours, on average it is believed that Nise relieves pain for 6-8 hours. But practice shows that Nise in most cases relieves pain for up to 12 hours.

How to use for toothache in children

Nise tablets can be given from 12 years of age.

It is recommended that children take Nise tablets when they reach 12 years of age. You can also focus on the child’s body weight; the figure should exceed 40 kg. The suspension is intended for children starting from 2 years of age.

The dosage for use is calculated based on the baby’s weight (5 ml of product per 1 kg). The resulting figure is divided into several steps, which are carried out throughout the day.

You should make an appointment with a doctor as soon as possible; Nise does not have a therapeutic effect on the progression of dental diseases.

How to apply

In tablet form

Nise in the form of tablets is most often indicated for adults and adolescents weighing more than 40 kilograms.

Features of the use of tablets:

• The medicine is taken one tablet at a time
• You can take up to 2-3 times per day
• If the need suddenly arises, the number of receptions can be increased up to 4 times. The main thing is that the interval between doses is at least 4 hours.
• It is recommended to dissolve Nise dispersible tablets in 1 teaspoon of boiled water. Next, the resulting solution is taken
• Regular tablets are taken orally without dissolution. Take extra water
• Tablets should be taken after eating

In the form of a suspension

The suspension is intended for children over 2 years of age and up to 12 years of age.

The dosage must be calculated according to body weight. 5 mg is indicated per 1 kilogram of weight. The resulting dosage is divided into two doses.

It is recommended to take the suspension before meals. However, in cases where the unpleasant sensations cause severe discomfort to the child, the drug can be given after eating.

The duration of administration of the suspension should not be more than 10 days. During this period, you must find time to take your child to an appointment with a pediatric dentist.

Contraindications

There are some restrictions regarding taking the drug that you should pay attention to when purchasing. The drug is contraindicated in cases where there are such health problems:

• disruptions in the functioning of the digestive system;
• stomach ulcer;
• intestinal infections;
• hepatitis (any type);
• internal bleeding and poor blood clotting;
• frequent problems with blood pressure;
• kidney and liver problems;
• cardiovascular diseases, attacks of bronchial asthma;
• polyps;
• frequent manifestation of dermatoses;
• eye diseases.

Age restrictions have also been established; the drug is recommended for children from 2 years of age. Pregnant and breastfeeding women should avoid using Nise, as should those who have an allergic reaction to the components of the product (especially aspirin).

It is important to note the property of drugs in this group to dull the reaction, which is due to the hypnotic effect. Therefore, people who spend most of their time driving or doing work that involves risking their lives are not recommended to take Nise.

Patients diagnosed with diabetes mellitus should first consult with their doctor about the possibility of using the drug.

For what indications should the drug not be used?

The analgesic drug Nise, like other similar drugs, has contraindications. Therefore, before using this medicine, you should carefully study the instructions.

Indications for which this drug is contraindicated include the following conditions:

• Presence of gastric and duodenal ulcers
• Should not be used for bronchial asthma
• Polyps in the nasopharynx area
• If there is renal, hepatic, heart failure
• Not recommended for use during diabetes
• If an allergic reaction occurs and individual intolerance to the constituent components, as well as aspirin
• Children under 2 years of age

In some cases, taking the medication is contraindicated

Also, the drug Nise is not recommended for use during pregnancy. The ingredients may cause serious harm to the baby. As a result, the child may be born with serious disabilities. Since the constituent substances may be excreted in breast milk, it is not recommended for use during breastfeeding.

Side effects

Ignoring contraindications or using Nise in combination with other medications, as well as alcohol, can cause side effects that manifest themselves as:

• dizziness, migraine attacks;
• nausea, vomiting;
• severe heartburn;
• formation of an allergic rash on the skin;
• diarrhea;
• physical weakness, drowsiness;
• signs of toxic hepatitis.

In this case, blood test parameters can change dramatically, reflecting a low level of leukocytes, anemia, thrombocytopenia, etc. In the case of a severe allergic reaction, anaphylactic shock is possible.

Advantages and disadvantages

Nise will help temporarily relieve toothache.

Toothache, as we know, is very difficult to endure, so the purpose of using the drug is to reduce the pain or completely eliminate it. Nise helps achieve this effect. Already 20-30 minutes after using the product, significant relief occurs. The body's reaction time to the dose taken depends on the individual characteristics of the person.

The main advantages of the pain reliever:

• rapid blocking of pain syndrome;
• can be purchased at any pharmacy at an affordable price;
• no doctor's prescription required;
• the drug is combined with other drugs of different groups (anti-inflammatory, antihistamines, antibiotics, etc.).

Disadvantages of Nise:

• eliminates pain only temporarily, the dental problem is not solved, so a trip to the doctor is inevitable;
• Before use, you should carefully read the contraindications; the drug has some restrictions, non-compliance with which causes serious health complications.

Pros and cons of the drug

Pros:

1. Available without a prescription.
2. Acts against pain and inflammation at the same time.
3. Well tolerated, side effects rarely occur.
4. Effective compared to other analgesics and non-steroidal anti-inflammatory drugs.
5. The therapeutic effect occurs quickly (20-30 minutes) and for a long time (on average 8-12 hours).
6. Relieves swelling, for example, during gum inflammation.
7. Reduces the temperature that can occur with dental diseases.
8. Available in two forms: tablets and soluble granules. A suspension prepared from granules acts faster than tablets.
9. It is preferable in the presence of ulcerative gastritis processes, in comparison with other anti-inflammatory and analgesic drugs.
10. The suspension can be given to young children from 2 years of age.

Minuses:

1. It has a negative effect on the liver, so long-term use is not recommended, as well as use in people with liver problems and in the elderly.
2. Can only be used in short courses.
3. Some people do not feel any pain relief.
4. Tablets should not be taken by children under 12 years of age, and the suspension should not be taken by children under 2 years of age.

Analogues for toothache and prices

Not every pain reliever is effective for toothache. The table shows examples of drugs that are recommended for use in the absence of Nise.

Ketanov Ketorol Nurofen Nimesil Nimesulide Tempalgin Spazmalgon Pentalgin

Popular questions

To make information about the drug Nise more complete and reliable, it is recommended that you familiarize yourself with popular questions. Having received answers to them, you will be able to use the pharmacological drug correctly, without harming your health and the lives of loved ones.

• How long does Nise last for toothache?

When entering the body, the substances included in the composition are quickly absorbed into the blood, as a result of which the pain sensations are weakened or disappear altogether. The effectiveness of the drug is high, its effect is observed even during acute attacks of toothache. However, Nise has no effect on the progression of the disease, and temporary relief is limited to four hours. Efficiency increases if the degree of painful manifestations is mild or moderate.

• How long does it take to work? How fast?

The action of the active components of the drug, aimed at dulling pain, begins 20 minutes after administration. The duration can increase to 30 minutes, which is due to the reaction and characteristics of the body in each individual case.

• How much can you drink per day?

For toothache, adults are recommended to take Nise 1 tablet up to 3 times a day with an interval of at least 3-4 hours. Reducing the time between use of the drug and increasing the dosage is allowed only in acute forms of pain. However, the total daily number of tablets should not exceed 4 pieces, which corresponds to a dosage of 200 mg. Children should not increase the dose above 150 mg.

Nise is available not only in tablets, but also in the form of ointment and gel. They have one main active ingredient – ​​nimesulide. However, this is not a basis for using ointment/gel to solve dental problems, since this form is intended for external use.

The drug Nise copes with pain quite effectively, so if repeated taking of the pill does not give the desired result, it is better to see a doctor as soon as possible. It’s not worth wasting time testing other painkillers; the situation can only get worse.