Comparison of the effectiveness of Tempalgin and Pentalgin
The effectiveness of Tempalgin is quite similar to Pentalgin - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Tempalgin is more pronounced, then using Pentalgin even in large doses will not achieve this effect.
Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Tempalgin and Pentalgin. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Efficiency
In this parameter, the drugs are very similar. The main active component of these products has the maximum effect on the problem.
At the same time, the therapeutic effect of Tempalgin is more pronounced. Even large dosages of Pentalgin will not be able to provide a similar result.
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In terms of treatment speed, Tempalgin and Pentalgin work approximately the same. Bioavailability refers to the amount of the active component that reaches its destination. According to this parameter, the drugs are identical. High bioavailability parameters ensure minimal losses during the absorption of the drug by the body.
Comparison of the safety of Tempalgin and Pentalgin
The safety of a drug includes many factors.
At the same time, it is higher for Pentalgin than for Tempalgin. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Pentalgin, as well as Tempalgin, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Pentalgin has fewer risks when used than Tempalgin.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Pentalgin and Tempalgin.
Safety of use
This parameter is influenced by many factors. "Pentalgin" is considered a safer drug than "Tempalgin". The site of metabolism is no less important. Metabolic process - the ability of a drug to be excreted from the body in its original form or in a processed form (biochemical transformations). Metabolism is a spontaneous phenomenon that involves the main human organs (brain, kidneys, skin, liver) in this process.
When comparing Pentalgin and Tempalgin, it is necessary to look at which organ is involved in the metabolic process, as well as the level of criticality of the drug’s effect on it.
When choosing a drug, you need to consider the benefit-risk ratio. In some cases, prescribing medication is undesirable, but justified. It is important to be very careful when doing this. Tempalgin has more risks when used than Pentalgin.
The level of safety of the drug depends on possible side effects, which are expressed in the form of allergies or other disorders of the patient’s main organs. It is also important to evaluate the reversibility of harm caused to the body after using medications.
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Comparison of addiction between Tempalgin and Pentalgin
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “o syndrome” in Tempalgin is quite similar to the similar values in Pentalgin. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, in Tempalgin the meaning of the “syndrome” is quite small, however, the same as in Pentalgin.
addictive
This evaluation parameter is influenced by many different factors that are important to consider when evaluating drugs. By addiction to a drug we mean the development of withdrawal syndrome and resistance. These indicators are similar for the drugs.
Withdrawal syndrome is a painful condition of the patient that appears after certain components of the drug stop entering the body.
Resistance is the initial rejection of a drug. That is, the immunity of the main substance can form over a certain period of time. Ascertainment of resistance occurs after an attempt to increase the dosage of the drug to the maximum possible level. The drugs "Tempalgin" and "Pentalgin" have insignificant resistance and withdrawal symptoms.
Comparison of side effects of Tempalgin and Pentalgin
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Pentalgin has more adverse effects than Tempalgin. This implies that the frequency of their occurrence is low in Pentalgin and low in Tempalgin. Frequency of manifestation is an indicator of how many cases of an undesirable effect from treatment are possible and registered. The undesirable effect on the body, the strength of influence and the toxic effect of drugs are different: how quickly the body recovers after taking it and whether it recovers at all. When using Pentalgin, the body's ability to recover faster is higher than that of Tempalgin.
Adverse reactions
By side effects we mean an adverse medical phenomenon that occurs in a patient after taking a medication. The list of possible adverse reactions of the body after taking drugs is approximately the same.
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Tempalgin has a shorter list of possible adverse reactions than Pentalgin. The frequency of their manifestation is lower in Tempalgin, and higher in Pentalgin. The frequency of side effects refers to the number of possible and recorded cases of adverse reactions. The drugs differ in their potency, toxicity, and overall effect on the body.
It is important to consider the period of time during which the body will return to normal and whether it will be able to restore its original state at all after taking medications. The body recovers faster after taking Pentalgin.
Tempalgin during pregnancy: main risks
The use of tempalgin is contraindicated during pregnancy due to the negative effect of the active ingredients of this combination drug.
Tempalgin has a wide range of therapeutic effects, consisting in the primary suppression of prostaglandin synthesis. Since prostaglandins take part not only in increasing the sensitivity of pain receptors and body temperature, but also in other important physiological processes, inhibition of their activity under the influence of Tempalgin can negatively affect the body of a pregnant woman and pregnancy in general. Studies on the effect of Tempalgin on pregnancy outcomes have not yet been conducted. However, there are some studies of the effect of the active ingredients of Tempalgin (metamizole and tempidone) on the outcome of pregnancy.
The Pharmacovigilance Center for Fetal Toxicology at the Institute of Clinical Pharmacology and Toxicology (Germany) conducted an observational cohort study of the effects of metamizole use in the first trimester of pregnancy.
This study compared pregnancy outcomes in 446 women who received metamizole in the first trimester with a randomly selected control group of 887 women who did not take metamizole. Relevant data were obtained using structured questionnaires administered during the first trimester and 2 months after the expected date of birth between January 2000 and December 2015.
As a result of the study, scientists concluded that exposure to metamizole in the first trimester of pregnancy does not carry a significant teratogenic risk due to the low toxicity of this drug.
A similar study was conducted by the Department of Neonatology, Hadassah University Hospital, Mount Scopus, Jerusalem, which assessed the teratogenic effect of metamizole when used in the first trimester of pregnancy.
Ultimately, the data obtained from the analysis showed that there was no teratogenic or toxic risk, as well as no malformations or the possibility of miscarriage.
The absence of the risk of congenital anomalies and other side effects from taking metamizole during pregnancy was also demonstrated by the Brazilian Federal University, assessing the risk of adverse perinatal effects in newborns receiving Dipirone during pregnancy. This study followed a total of 5,564 women aged 20 years or older who were between 21 and 28 weeks of pregnancy.
Despite the neutral results of various studies, taking Tempalgin is unacceptable, since metamizole is characterized by a wide list of side effects that can harm not only the pregnant woman, but also the fetus.
No specific studies have been found on Tempalgin’s second active ingredient, tempidone. But nevertheless, due to the fact that tempidone exhibits anxiolytic and antidepressant effects, it is contraindicated during pregnancy and can have the following effects:
- enter the child’s body through the placental barrier and cause side effects inherent in this drug, only in a more intensified form due to the increased susceptibility and sensitivity of the child’s body;
- may cause a withdrawal reaction in a child, namely a condition of the body that occurs when taking a drug is interrupted or reduced and can cause a deterioration in well-being.
How is Pentalgin different?
By the way, modern Pentalgin, which is produced on the territory of the Russian Federation, is not at all the familiar Soviet “five” that was well known to us and perfectly helped against headaches. Then its composition was a combination of analgin, paracetamol, caffeine, phenobarbital and codeine - drugs with a powerful analgesic potential against neurological pain, although quite strongly depressing the central nervous system. Currently, manufacturers have completely changed the composition of the modern product in favor of improving the safety profile and expanding the indications for use, but sacrificed analgesic activity.
It is now a combination of paracetamol, naproxen, drotaverine, pheniramine and caffeine.
- Paracetamol 325 mg is a non-narcotic analgesic with central action.
- Naproxen 100 mg is an NSAID that provides a peripheral anti-inflammatory effect that enhances and prolongs the effect of paracetamol.
- Drotaverine 40 mg is a myotropic antispasmodic, the active ingredient of the original drug “No-shpa”. Relaxes the smooth muscles of the intestines, urinary and biliary tracts, uterus, blood vessels.
- Caffeine 50 mg is a psychostimulant, in this case it enhances the analgesic effect of the main components.
- Pheniramine 10 mg is an antihistamine that increases the analgesic activity of paracetamol and naproxen.
Packaging 24 tab.
Analysis of indications for use:
- Pain syndromes of various origins (including muscle pain, joint pain, radiculitis, menstrual pain, neuralgia, toothache. Headache due to fatigue, migraine, vegetative-vascular dystonia... Stop. Vegetative-vascular dystonia is a mythical diagnosis that is used by domestic experts to designate situations when the doctor doesn’t know what’s wrong with you and doesn’t want to figure it out. Most often, the cause of such headaches is beyond his competence and is the lot of neurologists and psychotherapists.
The fact that the manufacturer, in the conditions of the development of modern science, makes medical archaism in recommendations for the use of the drug causes not only surprise, but also a certain awkwardness. Thank you, this information is only available on the official website. The instructions for Pentalgin are limited to “headaches caused by spasm of cerebral vessels" - also a rather vague term that combines various conditions from cervical osteochondrosis until a hangover.Migraine and migraine-like pain are no longer listed as indications in the instructions. - Pain caused by spasm of smooth muscles during cholecystitis, renal colic, cholelithiasis.
- Traumatic and postoperative pain with the presence of an inflammatory process.
- Fever due to colds.
Thus, the difference between the drugs lies not only in composition, but also in pharmacodynamics and indications for use.
Release form:
- Tem - table. 10 or 20 pcs per package.
- Pen-n - tab. 4, 12 or 24 pcs per package.
Manufacturer:
Tempalgin - Sopharma, Bulgaria. Sopharma is a pharmaceutical company with an 80-year history, its own production of substances and traditionally (since Bulgaria was a country of the former socialist camp) for more than 40 years focused on the production of medicines mainly for the countries of the post-Soviet space.
Pentalgin - Pharmstandard-Leksredstva OJSC, Kursk, Russia. Pharmstandard is the largest Russian pharmaceutical concern and declares modern production technologies and proper quality.
Price difference
On average, 24 tablets of Pentalgin will cost you 1.6 times more than your opponent’s pack of 20 tablets.
From the point of view of the reputation of manufacturers and the comparability of the price category, Tempalgin and Pentalgin are approximately equal. In order to determine which is better, you should be guided by the nature of the pain syndrome, taking into account the new composition and indications for use for Pentalgin. In any case, it must be remembered that combined analgesics are first aid products exclusively for pain relief, and are not intended for chronic treatment.
