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Manufacturers: Unique Equipments
Active ingredients
- Metronidazole
- Chlorhexidine
Disease class
- Diseases of the pulp and periapical tissues
- Periapical abscess without cavity
- Acute gingivitis
- Chronic gingivitis
- Acute pericoronitis
- Chronic periodontitis
- Periodontal disease
- Periodontal disease, unspecified
- Alveolitis of the jaws
- Recurrent oral aphthae
- Lip diseases
- Other and unspecified lesions of the oral mucosa
- Presence of dentures
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Antibacterial
- Antiseptic (disinfectant)
- Bactericidal
Pharmacological group
- Other synthetic antibacterial agents in combinations
- Dental products in combinations
Gel Metrogyl Denta
Instructions for medical use of the drug
Description of pharmacological action
It has an antibacterial effect against anaerobic bacteria that cause periodontal diseases: Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium fusiformis, Wolinella recta, Eikenella corrodens, Borrelia vincenti, Bacteroides melaninogenicus, Selenomonas spp.
Indications for use
Infectious and inflammatory diseases of periodontal and oral mucosa: - acute and chronic gingivitis; — acute ulcerative-necrotizing gingivitis of Vincent; — acute and chronic periodontitis; — juvenile periodontitis; - periodontal disease complicated by gingivitis; - aphthous stomatitis; - cheilitis; - inflammation of the oral mucosa when wearing dentures; — post-extraction alveolitis (inflammation of the socket after tooth extraction); - periodontitis, periodontal abscess (as part of combination therapy).
Release form
gel for use in dentistry; plastic tube of 5,10,20,30 or 50 g, cardboard pack 1; gel for use in dentistry; aluminum tube of 5,10,20,30 or 50 g, cardboard pack 1;
Pharmacodynamics
The effectiveness of the drug is due to the presence of two antibacterial components in its composition: a) metronidazole has an antibacterial effect against anaerobic bacteria that cause periodontal diseases: Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium fusiformis, Wolinella recta, Eikenella corrodens, Borrelia vincenti, Bacteroides melaninogenicus, Selenomonas spp. b) chlorhexidine is a broad-spectrum antiseptic that has a bactericidal effect against vegetative forms of gram-negative and gram-positive microorganisms, as well as yeast, dermatophytes and lipophilic viruses.
Pharmacokinetics
When applied topically, Metrogyl Denta gel is practically not absorbed.
Use during pregnancy
It is not recommended to prescribe the drug to pregnant women in the first trimester of pregnancy. During lactation, the issue of stopping breastfeeding should be decided.
Contraindications for use
individual intolerance to metronidazole, chlorhexidine, as well as nitroimidazole derivatives and any components included in the drug; children under 6 years of age.
Side effects
When using Metrogyl Denta gel topically, the risk of developing systemic side effects is low, but sometimes the following may occur: headache, allergic reactions (skin rash, itching, urticaria).
Directions for use and doses
Topically, for dental use only. For adults and children over 6 years old with gum inflammation (gingivitis), Metrogyl Denta is applied to the gum area 2 times a day; it is not recommended to wash off the gel. The duration of treatment is on average 7–10 days. After applying the gel, you should refrain from drinking and eating for 30 minutes. In case of periodontitis, after removing dental plaque, periodontal pockets are treated with Metrogyl Denta gel and the gel is applied to the gum area. Exposure time - 30 minutes. The number of procedures depends on the severity of the disease. In the future, the patient can apply the gel independently: Metrogyl Denta is applied to the gum area 2 times a day for 7–10 days. For aphthous stomatitis, Metrogyl Denta is applied to the affected area of the oral mucosa 2 times a day for 7–10 days. To prevent exacerbations of chronic gingivitis and periodontitis, Metrogyl Denta gel is applied to the gum area 2 times a day for 7–10 days. Preventive courses of treatment are carried out 2–3 times a year. To prevent post-extraction alveolitis after tooth extraction, the hole is treated with Metrogyl Denta® gel, then the gel is applied on an outpatient basis 2-3 times a day for 7-10 days.
Overdose
There were no cases of drug overdose with topical use.
Interactions with other drugs
When applied topically in recommended doses, no systemic interaction of Metrogyl Denta gel with other drugs was detected.
Special instructions for use
The use of Metrogyl Denta gel does not replace hygienic brushing of teeth, therefore, during the course of treatment with the drug, teeth brushing should be continued.
Storage conditions
List B.: At a temperature not exceeding 25 °C.
Best before date
36 months
ATX classification:
A Digestive tract and metabolism
A01 Dental preparations
A01A Dental preparations
A01AB Antimicrobials for topical use in diseases of the oral cavity
A01AB11 Other antimicrobials
Causes of aphthous stomatitis
Rashes in the form of aphthae on the oral mucosa can be the main manifestation of stomatitis if it occurs as an independent (primary) disease4. In other cases, ulcerations represent a symptom of another disease3,4. But determining the exact causes of inflammation is not so easy, because many different factors can trigger it5.
The development of acute aphthous stomatitis is often associated with a weakening of the body’s defenses after a cold (acute respiratory illness) or sore throat1.
The chronic form occurs under the influence of local and general factors5, among which are the following:
- Infection . The likelihood of aphthous stomatitis increases in the presence of chronic infections, such as tonsillitis (inflammation of the tonsils), pharyngitis (inflammation of the pharynx) and diseases of the gastrointestinal tract8.
- Local trauma. Not every damage to the mucous membrane leads to the formation of aft5. But in people with a hereditary predisposition, its injury quite often leads to ulceration5, especially in those who smoke or use dentures5,7.
- Dry mouth. Changes in the properties of saliva or its deficiency contribute to the aggravation of the symptoms of aphthous stomatitis5.
- Allergic reactions. Allergens can include food products10, components of toothpastes5,10, dust10, worms10, medications10 and materials from which dentures are made, for example, nickel5.
- Deficiency of certain nutrients . Inflammation is promoted by a lack of zinc, iron, folic acid, and group vitamins (B1, B2, B6, B12)5.
- Stress . Difficult experiences, mental overstrain5, chronic stress or frequent change of time zones8 often precede the appearance of new aphthae. In students, the disease often worsens during the session5,7,
- Hormonal disorders. In women, the development of the disease can be facilitated by hormonal changes during menstruation, pregnancy or menopause3.
With chronic aphthous stomatitis, an interesting reaction of the immune system is observed - its sensitivity to certain bacteria10 that inhabit the oral cavity increases7. When the immune response is excessive8, protective antibodies damage not only bacteria, but also their own cells7,8. The reason for this reaction is the presence of structures in the cells of the mucous membrane that are similar to bacterial particles6.
to come back to the beginning
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Metrogyl Denta, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Metrogyl Denta is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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How does aphthous stomatitis manifest?
The first manifestation of the disease may be a burning sensation in the mouth, which lasts from 2 hours to 2 days5. Later, aphthae5 appear on the mucous membrane - single or multiple12.
Aphthae can be recognized by the following signs:
- they form on the surface of the mucous membrane, representing a shallow defect2;
- covered with a gray-white coating12;
- surrounded by a reddish “rim”2;
- the shape of the ulcers is oval2 or elongated12, and the size in most cases is up to 1 cm in diameter2.
Ulcers can appear on any part of the oral mucosa, as well as on the tongue12. But usually they form where the submucosal layer is pronounced and can easily be damaged2 - this is the area of the cheeks, lips, floor of the mouth (under the tongue) and palate2, 12.
Aphthae are quite painful12, and they cause pain not only during eating or talking, but also at “rest”1, when nothing irritates the mucous membrane.
In addition to pain, aphthous stomatitis causes excessive salivation6 and bad breath1.
to come back to the beginning
Does smoking affect the effectiveness of use?
Dentists note that about 50% of patients seeking dental care suffer from tobacco addiction. Smoking negatively affects the condition of the mucous membranes, reduces local immunity and causes irritation of the gums. Tobacco smoke interferes with the healing of the hole after extraction and can become one of the factors provoking postoperative complications, so doctors recommend stopping (or at least reducing the number of cigarettes smoked) during the recovery period after surgery.
Important! Smoking is not a contraindication for the use of Metrogyl Denta, but it significantly reduces the effectiveness of therapy, preventing rapid healing of the socket and tissue regeneration.
Are there any restrictions during pregnancy?
Tooth extraction is rarely performed during pregnancy - only in cases where there are emergency indications that threaten the course of pregnancy and the health of the woman and fetus. If the doctor believes that removal cannot be avoided, it is very important to follow all the specialist’s recommendations in the postoperative period, even if the expectant mother feels well. The natural decrease in immunity during pregnancy contributes to the rapid growth of pathogenic flora in case of penetration of bacteria and microbes into the oral cavity, therefore it is important to provide antiseptic treatment with the help of drugs prescribed by a doctor.
The official instructions indicate the first trimester of pregnancy as a contraindication for use, but in rare cases, the doctor may prescribe this remedy in the early stages of pregnancy (up to 12-14 weeks). It is important to follow the indicated dosages and number of uses per day. In the 2nd and 3rd trimesters, the use of the gel is safe and does not affect the condition and growth of the fetus due to the low absorption of the active ingredients.
Important! At any stage of pregnancy, before using Metrogyl Denta, it is better to consult a doctor. Women who are breastfeeding must stop lactation for the period of treatment.
Why is the drug prescribed after tooth extraction?
After a tooth is extracted, an open wound remains on the surface of the gum, allowing access to exposed bone tissue. To prevent the inflammatory process, immediately after removal, the doctor places a gauze swab soaked in hemostatic and antiseptic compounds into the hole. The tampon or turunda must be kept for 15-30 minutes, after which it must be removed.
Within 20-30 minutes after surgery, the hole is filled with blood, which quickly coagulates and forms a dense blood clot. This clot protects the wound from dirt, germs, bacteria and food debris. It is very important not to touch the clot with your tongue or allow it to dislodge in order to prevent infection from entering the socket and avoid inflammation. Before surgery, be sure to warn your doctor about taking any medications, because some of them (for example, drugs based on acetylsalicylic acid) can thin the blood and increase the risk of postoperative bleeding.
After surgery, Metrogyl Denta is prescribed to prevent infectious and inflammatory processes, reduce swelling and pain, and disinfect the oral cavity. The most common complications of extraction include the following pathologies:
- alveolitis – inflammation of the tooth socket (“dry socket”);
- infectious lesions of the soft tissues surrounding the tooth;
- periostitis – damage to the periosteum, accompanied by swelling of the gum tissue and severe pain;
- purulent abscess.
For several days after surgery, the patient may experience moderate or intense pain, swelling and swelling of the gums. The bleeding should completely subside on the third day - if this does not happen, you should consult a doctor.
"Metrogil Denta" helps to quickly relieve inflammation, reduce the severity of pain and prevent the development of an infectious process in the oral cavity.
