Solcoseryl dental adhesive paste for topical use, 5 g

pharmachologic effect

Combined preparation for local use, stimulator of tissue regeneration.

The drug is a chemically and biologically standardized deproteinized dialysate obtained from the blood of healthy dairy calves using the ultrafiltration method. Contains a wide range of natural low-molecular compounds weighing up to 5000 Daltons: glycolipids, nucleosides and nucleotides, amino acids, oligopeptides, trace elements, electrolytes, intermediate products of carbohydrate and fat metabolism. Activates the transport of oxygen and nutrients at the cellular level, increases oxygen consumption by the cell, stimulates ATP synthesis, enhances the proliferation of reversibly damaged cells, especially under hypoxic conditions, thereby accelerating wound healing processes. Stimulates angiogenesis, promotes revascularization of ischemic tissue, as well as creating conditions favorable for collagen synthesis and the growth of fresh granulation tissue, accelerates re-epithelialization and wound closure. The drug also has membrane-stabilizing and cytoprotective effects.

Polidocanol 600 - local anesthetic; acts in the area of ​​peripheral nerve endings, causing their reversible blocking. It has a quick and long-lasting local anesthetic effect. After applying the paste to the oral mucosa, the pain stops within 2-5 minutes; pain relief lasts for 3-5 hours.

Solcoseryl dental adhesive paste forms a protective healing layer on the affected area of ​​the oral mucosa and protects it from mechanical and chemical damage for 3-5 hours, performing the function of a medicinal bandage.

Solcoseryl

The drug solcoseryl is a deproteinized, chemically and biologically standardized hemodialysate obtained from the blood of dairy calves using the ultrafiltration method. A drug substance is a combination of many low-molecular components of the cell mass, including glycoproteins, nucleotides, nucleosides, amino acids, oligopeptides, electrolytes, microelements, intermediate products of lipid and carbohydrate metabolism. This drug activates tissue metabolism, stimulates the processes of cellular nutrition and restoration. Solcoseryl provides more active transport of oxygen, glucose and other nutrients to tissues under conditions of oxygen starvation, stimulates the synthesis of intracellular ATP, promotes the growth and reproduction of reversibly damaged cells (which is especially important under hypoxic conditions), accelerating wound healing. The drug triggers the formation of new blood vessels, promotes the restoration of blood vessels in ischemic tissues and the growth of fresh granulation tissue, creates favorable conditions for the synthesis of the main structural protein of the body - collagen, accelerates the growth of epithelium on the wound surface, resulting in wound closure. Solcoseryl is also endowed with cytoprotective and membrane-stabilizing effects.

The drug is available in five dosage forms: solution for intravenous and intramuscular administration, ophthalmic gel, paste for topical use, gel and ointment for external use. The protective effect of the eye gel is to stimulate re-epithelialization of the cornea after various damaging effects on it: these can be chemical burns (for example, alkali), mechanical injuries, inflammatory processes. In addition to the active substance, this dosage form contains sodium carmellose, which ensures uniform and long-lasting coverage of the cornea, so that the affected area of ​​tissue is uninterruptedly saturated with the drug.

Eye gel is the only dosage form of solcoseryl that has restrictions for use in cases of engaging in potentially hazardous activities (driving a car, working in production): in such cases, after applying the gel to the cornea, it is necessary to suspend your activity for 20-30 minutes.

An additional component of solcoseryl dental adhesive paste is polidocanol 600, a local anesthetic whose action is realized at the level of peripheral nerve endings, causing their temporary blocking. This substance has a quick and long-lasting local analgesic effect. After applying dental paste to the oral mucosa, the pain stops after 2-5 minutes, and this effect persists for another 3-5 hours. Solcoseryl dental paste forms a protective healing layer on the affected area of ​​the oral mucosa and effectively protects it from various types of damage. Meanwhile, this dosage form has a number of restrictions for use: for example, it is not recommended to put it into the cavity formed after the removal of wisdom teeth, molars and resection of the apex of the tooth (in the latter case, if sutures are applied after tightening the edges of the socket). The paste does not contain antibacterial components, therefore, in case of infection of the oral mucosa, before using solcoseryl, it is necessary to carry out a preventive medicinal “cleansing” in order to eliminate the causative agent of the infection and relieve inflammatory symptoms.

Solcoseryl gel for topical use is easily washed off from wound surfaces, because... does not contain fats as excipients. It promotes the formation of young connective (granulation) tissue and the resorption of exudate. From the moment fresh granulations form and the affected areas dry out, it is recommended to use solcoseryl in the form of an ointment, which, unlike the gel, already contains fats that form a protective film on the wound.

Directions for use and dosage

The drug is intended for local use on the oral mucosa.

The affected surface of the mucous membrane must first be dried with a cotton or gauze swab. Apply a strip of paste about 0.5 cm long, without rubbing, onto the mucous membrane in a thin layer with your finger or using a cotton swab, and then lightly moisten the applied paste with water. The procedure is repeated 3-5 times a day after meals and before bedtime. Treatment is carried out until symptoms disappear.

Solcoseryl dental adhesive paste forms a protective therapeutic layer on the affected area of ​​the oral mucosa and protects it from mechanical and chemical damage for 3-5 hours. When applying the paste to undried mucosa, the duration of the therapeutic effect can be reduced.

When treating bedsores from removable dentures, apply the paste to a dry denture and moisten with water.

The recommended course dose of the drug is 1 tube (5 g).

Solcoseryl (gel), 1 pc., 20 g, gel for external use

Solcoseryl injection solution:
IV
or
IM
.

In the treatment of occlusive diseases of peripheral arteries in stages III–IV according to Fontaine

- IV 20 ml daily. Intravenous drip administration in isotonic sodium chloride solution or 5% glucose solution is possible. The duration of therapy is up to 4 weeks and is determined by the clinical picture of the disease.

In the treatment of chronic venous insufficiency accompanied by trophic disorders (Ulcera cruris)

- IV 10 ml 3 times a week. The duration of therapy is no more than 4 weeks and is determined by the clinical picture of the disease. An important additional measure aimed at preventing peripheral “venous” edema is the application of a pressure bandage using an elastic bandage.

In the presence of local trophic tissue disorders, simultaneous therapy with Solcoseryl jelly and then Solcoseryl ointment is recommended.

In the treatment of ischemic and hemorrhagic strokes in severe and extremely severe forms

as the main course - 10 or 20 ml intravenously, respectively, daily for 10 days. Upon completion of the main course - 2 ml intramuscularly or intravenously for 30 days.

Traumatic brain injury (severe brain contusion)

- IV 1000 mg, daily for 5 days.

If intravenous administration of the drug is not possible, the drug can be administered intramuscularly, usually 2 ml per day undiluted.

When using the undiluted drug intravenously, it must be administered slowly, since it is a hypertonic solution.

Solcoseryl gel, ointment:
topically.
Apply directly to the wound surface after preliminary cleansing of the wound using a disinfectant solution.

Before starting treatment of trophic ulcers, as well as in cases of purulent infection of the wound, preliminary surgical treatment is necessary.

Solcoseryl gel is applied to fresh wounds, wounds with wet discharge, and to ulcers with signs of weeping - a thin layer on a cleaned wound 2-3 times a day. It is recommended to lubricate areas where epithelization has begun with Solcoseryl ointment. The use of Solcoseryl gel continues until pronounced granulation tissue forms on the damaged skin surface and the wound dries out.

Solcoseryl ointment is used primarily for the treatment of dry (non-wetting) wounds.

Solcoseryl ointment is applied in a thin layer to a cleaned wound 1-2 times a day; it can be used under bandages. The course of treatment with Solcoseryl ointment continues until the wound is completely healed, its epithelization and the formation of elastic scar tissue.

For the treatment of severe trophic damage to the skin and soft tissues, the simultaneous use of parenteral forms of Solcoseryl is recommended.

Pharmacodynamics

Solcoseryl is a chemically and biologically standardized deproteinized dialysate obtained from the blood of healthy dairy calves by ultrafiltration. Solcoseryl contains a wide range of natural low-molecular compounds weighing up to 5000 Da: glycolipids, nucleosides and nucleotides, amino acids, oligopeptides, trace elements, electrolytes, intermediate products of carbohydrate and fat metabolism. Solcoseryl activates the transport of oxygen and nutrients at the cellular level, increases oxygen consumption by the cell, stimulates ATP synthesis, enhances the proliferation of reversibly damaged cells, especially under hypoxic conditions, thereby accelerating wound healing processes. Solcoseryl stimulates angiogenesis, promotes revascularization of ischemic tissue, as well as the creation of conditions favorable for collagen synthesis and the growth of fresh granulation tissue, accelerates re-epithelialization and wound closure. Solcoseryl also has membrane-stabilizing and cytoprotective effects.

Polidocanol 600 - local anesthetic; acts in the area of ​​peripheral nerve endings, causing their reversible blocking. It has a quick and long-lasting local anesthetic effect. After applying the paste to the oral mucosa, the pain stops within 2–5 minutes; pain relief lasts for 3–5 hours.

Solcoseryl dental adhesive paste forms a protective healing layer on the affected area of ​​the oral mucosa and protects it from mechanical and chemical damage for 3–5 hours, performing the function of a medicinal bandage.

Indications for the drug Solcoseryl dental adhesive paste

Solcoseryl dental adhesive paste is used in patients of all age groups to locally accelerate healing, relieve pain and protect the wound surface in the following diseases and conditions:

— gingivitis and periodontal diseases, incl. after surgical interventions, installation of implants, removal of tartar;

- bedsores from removable dentures during the period of adaptation to them;

- alveolitis;

- stomatitis;

- lesions of the oral mucosa due to pemphigus;

- aphthae;

- jams.

Composition and release form

in tubes of 5 g; 1 tube in a box.

Solcoseryl dental adhesive paste for topical use, 5 g

Registration Certificate Holder

MEDA PHARMACEUTICALS SWITZERLAND (Switzerland)

Dosage form

Medicine - Solcoseryl dental adhesive paste

Description

Paste for topical use

in the form of a pale beige mass, granular, homogeneous, easily distributed, with the smell of peppermint.

1 g

standardized deproteinized dialysate from the blood of healthy dairy calves (in terms of dry matter) 2.125 mg lauromacrogol 400 (polidocanol 600) 10 mg

Preservatives:

methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216).

Excipients

: sodium carboxymethylcellulose, peppermint oil, menthol.

Paste base:

sodium carboxymethylcellulose, gelatin, pectin, polyethylene 350,000, liquid paraffin.

5 g - aluminum tubes (1) - cardboard packs.

Indications

For topical use in patients of all age groups to accelerate healing, relieve pain and protect the wound surface in the following diseases and conditions:

• gingivitis and periodontal diseases, incl. after surgical interventions, installation of implants, removal of tartar;
• bedsores from removable dentures during the period of adaptation to them;
• alveolitis;
• stomatitis;
• lesions of the oral mucosa due to pemphigus;
• aphthae;
• jams.

Contraindications for use

• hypersensitivity to the components of the drug, including free parahydrobenzoic acid (E 210), the presence of a residual amount of which is due to the peculiarities of the technological process during the production of the drug.

pharmachologic effect

Combined preparation for local use, stimulator of tissue regeneration.

The drug is a chemically and biologically standardized deproteinized dialysate obtained from the blood of healthy dairy calves using the ultrafiltration method. Contains a wide range of natural low-molecular compounds weighing up to 5000 Daltons: glycolipids, nucleosides and nucleotides, amino acids, oligopeptides, trace elements, electrolytes, intermediate products of carbohydrate and fat metabolism. Activates the transport of oxygen and nutrients at the cellular level, increases oxygen consumption by the cell, stimulates ATP synthesis, enhances the proliferation of reversibly damaged cells, especially under hypoxic conditions, thereby accelerating wound healing processes. Stimulates angiogenesis, promotes revascularization of ischemic tissue, as well as creating conditions favorable for collagen synthesis and the growth of fresh granulation tissue, accelerates re-epithelialization and wound closure. The drug also has membrane-stabilizing and cytoprotective effects.

Polidocanol 600 - local anesthetic; acts in the area of ​​peripheral nerve endings, causing their reversible blocking. It has a quick and long-lasting local anesthetic effect. After applying the paste to the oral mucosa, the pain stops within 2-5 minutes; pain relief lasts for 3-5 hours.

Solcoseryl dental adhesive paste forms a protective healing layer on the affected area of ​​the oral mucosa and protects it from mechanical and chemical damage for 3-5 hours, performing the function of a medicinal bandage.

Drug interactions

To date, there have been no cases of interaction between Solcoseryl dental adhesive paste and other drugs.

When simultaneously prescribing Solcoseryl dental adhesive paste and other drugs in the form of rinses, the paste should be applied after using these drugs.

Dosage regimen

The drug is intended for local use on the oral mucosa.

The affected surface of the mucous membrane must first be dried with a cotton or gauze swab. Apply a strip of paste about 0.5 cm long, without rubbing, onto the mucous membrane in a thin layer with your finger or using a cotton swab, and then lightly moisten the applied paste with water. The procedure is repeated 3-5 times a day after meals and before bedtime. Treatment is carried out until symptoms disappear.

Solcoseryl dental adhesive paste forms a protective therapeutic layer on the affected area of ​​the oral mucosa and protects it from mechanical and chemical damage for 3-5 hours. When applying the paste to undried mucosa, the duration of the therapeutic effect can be reduced.

When treating bedsores from removable dentures, apply the paste to a dry denture and moisten with water.

The recommended course dose of the drug is 1 tube (5 g).

Overdose

There is no information on the effects of an overdose of the drug.

Side effect

Local reactions:

change in taste sensations; Allergic reactions (local swelling) are possible; if these occur, the patient should stop using the drug and consult a doctor.

special instructions

You should not put Solcoseryl dental adhesive paste into the wound cavity formed as a result of the removal of molars, wisdom teeth, as well as apicotomy (resection of the apex of the tooth), if the edges of the tooth socket are tightened with subsequent sutures.

Solcoseryl dental adhesive paste does not contain antimicrobial components. In case of acute infection of the affected area of ​​the oral mucosa, which is subject to treatment with this drug, it is necessary to carry out preliminary medical treatment/treatment of the affected area aimed at eliminating the symptoms of inflammation.

There are no restrictions regarding the use of the drug in elderly patients.
Use in pediatrics
There are no restrictions on the use of the drug in children.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 30°C.

Best before date

Shelf life: 4 years.

The granular-dry consistency of the paste ensures its optimal adhesive properties and is not a sign of deterioration in the quality of the drug. When opening the tube, oil may be released, which is also not a sign of deterioration in the quality of the drug.

Use during pregnancy and breastfeeding

Restrictions during pregnancy - With caution. Restrictions when breastfeeding - With caution.

There are no contraindications to the use of Solcoseryl dental adhesive paste during pregnancy and lactation (breastfeeding), although special controlled studies on the safety of the drug in women during pregnancy and lactation have not been conducted.

Use in elderly patients

Restrictions for elderly patients - No restrictions.

There are no restrictions regarding the use of the drug in elderly patients.

Use in children

Restrictions for children - No restrictions.

There are no restrictions regarding the use of the drug in children.

Terms of sale

The drug is approved for use as a means of OTC.

Contacts for inquiries

MYLAN PHARMA LLC (Russia)

109028 Moscow, Serebryanicheskaya embankment. 29 Business North Side, fl. 9 Tel. Fax