The effect of Mexidol on soft tissues of the oral cavity in conditions of dental pathology


Manufacturer information

Mexidol toothpaste is produced by Pharmsoft, which has been supplying its products to the oral care market for 20 years. The company's employees are constantly improving the product, making it safer and more effective for solving dental problems.

The main component included in the lines of the paste in question is Mexidol. It is developed by the company itself. The peculiarity of the component is that it is able to eliminate signs of inflammation of periodontal tissues in the shortest possible time.

Composition of the drug

Each component included in the drug is characterized by a distinctive therapeutic effect. Mexidol (active substance) is a powerful antioxidant that quickly stops inflammatory processes and prevents the risk of infection of the soft tissues of the mouth with pathogenic microorganisms. The main component is also characterized by wound healing and immunomodulatory effects.

Another important ingredient in the drug is xylitol, which protects teeth from carious destruction. The substance also normalizes the acid-base balance in the mouth and prevents the active reproduction of pathogenic flora. Mexidol is considered a safe drug due to the moderate concentration of active substances in its composition.

The main difference between the paste and other oral care products is the absence of fluoride and chlorhexidine, which in some cases have a negative effect on the condition of the soft tissues of the mouth and enamel.


Fluoride is especially dangerous for people living in regions with high concentrations of the chemical element. For them, pastes can cause the formation of tartar, yellowing of the enamel or irreversible changes in the structure of the teeth

Advantages

The popularity of the pastes produced by this manufacturer has been facilitated by a number of advantages that they possess. The main thing among them is that they all do not contain fluorine and chlorhexidine.

To avoid undesirable consequences, pastes must be used in the correct dosage. It has been proven that excess fluoride can provoke the development of such a dangerous disease as fluorosis, which is accompanied by changes in the structure of the enamel. Also, if this component enters the body excessively, disruptions in the functioning of individual body systems may occur.

With the constant intake of excess amounts of chlorhexidine into the body, dysbiosis may develop due to the fact that pastes from this manufacturer have high antibacterial activity. Also, a negative effect can manifest itself in a change in the color of the teeth.

Therapeutic effect of the drug

The main component of Mexidol paste is used as an antioxidant, membrane protector, and antihypoxant. In the treatment of various diseases, Mexidol-based drugs are administered intravenously and intramuscularly. For the treatment of ophthalmological disorders, eye drops based on the component are used.

The substance has a pronounced anti-inflammatory effect, helps normalize hematopoiesis and intracranial pressure. Mexidol is also used as a prophylaxis for atherosclerotic pathologies.

Dentists warn that the anti-inflammatory and regenerating effect of the active component of Mexidol paste on teeth and gums has not been scientifically confirmed. They believe that the therapeutic effect of the gel described on the manufacturer’s website is nothing more than an advertising ploy. The complex effect of the paste has not been confirmed by the international medical community.

Mexidol paste cannot be used as monotherapy for dental disorders. It can only be used as part of a comprehensive treatment for pathologies of the gums and teeth.

Mexidol® (Mexidolum®)

IM or IV (stream or drip).

When administered by infusion, the drug should be diluted in 0.9% sodium chloride solution.

Mexidol® is injected slowly over 5-7 minutes in a stream, and dropwise at a rate of 40-60 drops per minute. The maximum daily dose should not exceed 1200 mg.

For acute cerebrovascular accidents

Mexidol® is used in the first 10-14 days - 200-500 mg IV drip 2-4 times a day, then 200-250 mg IM 2-3 times a day for 2 weeks.

For traumatic brain injury and consequences of traumatic brain injury

Mexidol® is used for 10-15 days intravenously at a dose of 200-500 mg 2-4 times a day.

For dyscirculatory encephalopathy in the decompensation phase

Mexidol® should be prescribed intravenously in a stream or drip at a dose of 200-500 mg 1
-
2 times a day for 14 days. Then IM 100-250 mg/day. over the next 2 weeks.

For course prophylaxis of dyscirculatory encephalopathy

the drug is administered intramuscularly at a dose of 200-250 mg 2 times a day for 10-14 days.

For mild cognitive impairment in elderly patients and anxiety disorders

the drug is used intramuscularly at a daily dose of 100-300 mg/day for 14-30 days.

In acute myocardial infarction as part of complex therapy

Mexidol® is administered intravenously or intramuscularly for 14 days, against the background of traditional therapy for myocardial infarction, including nitrates, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, thrombolytics, anticoagulant and antiplatelet agents, as well as symptomatic agents according to indications.

In the first 5 days, to achieve maximum effect, it is advisable to administer the drug intravenously; in the next 9 days, Mexidol® can be administered intramuscularly. Intravenous administration of the drug is carried out by drip infusion, slowly (to avoid side effects) in a 0.9% sodium chloride solution or 5% dextrose (glucose) solution in a volume of 100-150 ml for 30-90 minutes. If necessary, a slow jet injection of the drug, lasting at least 5 minutes, is possible.

The drug is administered (intravenous or intramuscular) 3 times a day, every 8 hours. The daily therapeutic dose is 6-9 mg/kg body weight per day, a single dose is 2-3 mg/kg body weight. The maximum daily dose should not exceed 800 mg, single dose - 250 mg.

For open-angle glaucoma of various stages as part of complex therapy

Mexidol® is administered intramuscularly at 100-300 mg/day, 1-3 times a day for 14 days.

For alcohol withdrawal syndrome

Mexidol® is administered in a dose of 200-500 mg intravenously or intramuscularly 2-3 times a day for 5-7 days.

In case of acute intoxication with antipsychotic drugs

the drug is administered intravenously at a dose of 200-500 mg/day for 7-14 days.

In acute purulent-inflammatory processes of the abdominal cavity (acute necrotizing pancreatitis, peritonitis)

the drug is prescribed on the first day both in the preoperative and postoperative periods. The administered doses depend on the form and severity of the disease, the prevalence of the process, and variants of the clinical course. The drug should be discontinued gradually only after a stable positive clinical and laboratory effect.

For acute edematous (interstitial) pancreatitis

Mexidol® is prescribed 200-500 mg 3 times a day, intravenously (in 0.9% sodium chloride solution) and intramuscularly.

Mild severity of necrotizing
pancreatitis
- 100-200 mg 3 times a day intravenously (in 0.9% sodium chloride solution) and intramuscularly.

Moderate severity

- 200 mg 3 times a day, intravenously (in 0.9% sodium chloride solution).

Severe course

— in a pulse dosage of 800 mg on the first day, with a two-time administration regimen; then 200-500 mg 2 times a day with a gradual reduction in the daily dose.

Extremely severe course

- at an initial dosage of 800 mg/day until the manifestations of pancreatogenic shock are persistently relieved, upon stabilization of the condition, 300-500 mg 2 times a day intravenously (in 0.9% sodium chloride solution) with a gradual decrease in the daily dosage.

Indications for use

Mexidol series toothpastes have their own indications for use:

  • gingivitis;
  • hemorrhages on the mucous membranes of the mouth;
  • carious tooth decay;
  • damage to the oral mucosa (burns, mechanical injuries);
  • periodontitis;
  • periodontal disease.

The drug has few contraindications: sensitivity to the active and auxiliary components of the drug, pregnancy and breastfeeding, children under 12 years of age. In the latter case, it is better to purchase special preparations designed to care for thin tooth enamel and sensitive periodontal tissues.


The best oral care products for children - Rox, Splat, President (baby)

Contraindications

Contraindications to hygiene products are:

  1. Allergy to toothpaste components.
  2. Children under 12 years of age.
  3. The period of bearing a child.
  4. Lactation period.

Toothpastes made by have proven themselves well among dental patients. This is evidenced by patient reviews and clinical observations of doctors. Pastes with such an expanded composition make it possible to prevent and fight most dental diseases. They can reduce sensitivity, reduce bleeding gums and much more.

In addition, thanks to the low cost of the Mexidol series pastes, they are available to anyone. Dentists recommend their patients to use such pastes if a diagnosis of stomatitis, periodontitis, periodontal disease and gingivitis, etc. is established.

Author: Natalya Stagurskaya, dentist, especially for Karies.pro

Product lines

Each type of Mexidol paste differs in composition and spectrum of action. The range of toothpastes in question should be considered.

Mexidol Dent Aktiv (Mexidol Dent Active)

The product is used to prevent periodontitis and gingivitis. The gel contains 2 active components - xylitol and mexidol. Xylitol gives the paste a sweetish taste and acts as an abrasive component of the gel. The drug not only prevents periodontitis, but also allows it to be treated in the initial stages of development.

The Mexidol Dent Aktiv product has a powerful anti-inflammatory effect due to the inclusion of titanium dioxide and trisodium phosphate. With regular use of the product, it is possible to improve the blood supply to the gums and reduce the duration of dental diseases. The paste can effectively eliminate bacterial plaque on enamel and prevent dental caries.

The gel has a sweetish taste and pink tints. One tube of the drug costs from 80 to 140 rubles.

Mexidol Dent Complex (Mexidol Dent Complex)

The drug, as the name implies, has a complex effect and, with regular use, can solve a range of dental problems:

Tartar paste

  • restore damaged periodontal tissue;
  • strengthen gum tissue;
  • eliminate caries at the spot stage.

The Mexidol line of pastes is recommended for the following types of problems:

  • increased sensitivity of enamel to external irritants;
  • inflammatory processes of periodontium;
  • tendency to carious tooth decay.

The paste, in addition to xylitol and Mexidol, additionally contains calcium citrate. The last component is a water-soluble calcium salt, which easily penetrates into the upper layers of the tooth and fills the microcracks and voids existing on it. Due to this effect, it is possible to achieve strengthening of the enamel.

Reducing tooth sensitivity with Mexidol Dent Complex can only be achieved with constant use of the drug. The product has a medium level of abrasiveness. The cost of one tube of paste is 150 rubles.

Mexidol Dent Sensitive (Mexidol Dent Sensitive)

The drug has a minimal level of abrasiveness, unlike other lines of Mexidol pastes. The main indication for use of the drug is increased sensitivity of the enamel. The main active component in the gel is potassium nitrate. It has an anesthetic effect on the nerve fibers of the teeth located in the pulp. The effect is observed within a few minutes after applying the gel to the surface of the teeth.

Mexidol Dent Sensitive is suitable not only for cleansing the oral cavity of bacterial plaque and food debris. If teeth are sore, it can be used in the form of applications. To do this, a small amount of gel is squeezed onto the problematic crown and left for 5–7 minutes. The paste is not suitable for regular use due to its low cleaning abilities.


The maximum possible time for using Mexidol Dent Sensitive paste is 1 month

The drug is able to have an inhibitory effect on the pathogenic flora of the oral cavity due to the inclusion of xylitol and mexidol. You can purchase the product at the pharmacy for a price starting from 120 rubles.

Mexidol Dent Fito (Mexidol Dent Fito)

The product is an improved version of the drug Mexidol Active. In addition to the active components included in the earlier product under consideration, it also contains pine needle and plantain extract. The first component is distinguished by powerful antimicrobial activity and improvement of metabolic processes in gum tissue. Plantain extract is characterized by hemostatic properties. The effect of using the product is observed after several teeth cleaning procedures.

Indication for use of the paste is periodontitis of any degree of complexity. The drug is characterized by an average degree of abrasiveness and low cost - up to 100 rubles. for one package.

Professional White

The product is intended for whitening the crowns of teeth. The powerful therapeutic effect of the gel is due to the variety of components it contains:

  • Licorice extract. It is characterized by antimicrobial activity and effects on bacteria that cause caries.
  • Mexidol. It has a restorative and strengthening effect, which is especially necessary for the restoration of damaged gum tissue.
  • Papain is a natural enzyme. The component is able to dissolve dental plaque, thereby minimizing the risk of developing dental disorders. Thanks to the safe removal of plaque, it is possible to lighten the crowns of the elements by several tones.
  • Double calcium (calcium citrate and hydroxyapatite). Thanks to the combination of components, it is possible to strengthen the enamel. The components are capable of filling pores on the surface of teeth and masking microcracks on their surface.
  • Pyrophosphates. The substances prevent the reappearance of bacterial deposits on tooth enamel. They also prevent inflammation of periodontal pockets.

Thanks to its rich composition, Professional White not only whitens teeth, but also solves a range of dental disorders. The product can be purchased at the pharmacy for 180 rubles.

The Mexidol line of products does not contain pastes intended for the care of children's oral cavity. However, the gentle composition of the pastes makes them suitable for use by children over 12 years of age. From adolescence, it is also allowed to use mouthwashes from the series in question.

Assets


This paste is intended to provide effective prevention, as well as to treat and eliminate the symptoms of periodontitis and gingivitis. In addition to the main components, this product also includes trisodium phosphate and titanium dioxide.

The list of functions is quite wide:

  • relieving inflammation;
  • improvement of microcirculation;
  • reduction of bleeding;
  • removal of puffiness;
  • acceleration of regenerative processes of damaged gums;
  • general strengthening of the gums;
  • elimination of foci of infection;
  • removing plaque from enamel.

This toothpaste is pink in color and has a refreshing mint flavor. It has an average abrasiveness rating. The average cost is about 100 rubles, and the price range is from 75 to 140 rubles

.

Mouthwash Mexidol

The paste manufacturer also offers customers several types of rinses:

  • Mexidol Dent. The product does not contain alcohol or other aggressive chemical compounds. Licorice extract provides an antibacterial effect on the oral cavity. The mouthwash minimizes the signs of bleeding gums and fights bad breath. The liquid can be used in combination with any toothpaste.
  • Mexidol Dent Professional. Also free of alcohol and chemicals. Designed to lighten enamel and prevent dental problems. The mouthwash is suitable for regular use as it is not addictive.

Among the properties of rinses are:

  • improving blood supply to gum tissue;
  • relieving inflammation in the soft tissues of the mouth;
  • prevention of caries and periodontitis;
  • stimulation of metabolic processes in the oral cavity;
  • wound healing.


Mexidol rinses can be used on an ongoing basis, due to the fact that they do not affect the microflora of the oral cavity. The components of the product do not provoke irritation of the mucous membranes due to the gentle composition

To treat the mouth, use a measuring cup into which 10 ml of the product is poured. The rinse aid does not require preliminary dilution with water. The oral cavity treatment procedure is performed within 1 minute.

Grocery list

All pastes are produced in soft tubes covered with laminate. Their capacity is 65 g. The tube is sold in a cardboard packaging case. Each product also comes with instructions for use.

Main line

  • Aktiv (Active)
    - exhibits a pronounced, very strong anti-inflammatory effect.
  • Fito (Phyto)
    - contains plant components and extracts, due to which it has an antibacterial effect.
  • Sensitive
    - gently eliminates inflammation that occurs with periodontal diseases, and also reduces the sensitivity of not only the gums and teeth themselves, but also the exposed cervical areas.
  • Complex
    - has a systematic full-scale effect - relieving inflammation in the periodontal tissues, as well as treatment and further prevention of caries.
  • White
    – soft and effective whitening and antibacterial effect.

Rinse aid

In addition to toothpastes, this list also includes mouthwash, which is recommended for use with toothpastes.

. It contains the active ingredient Mexidol and licorice extract, which is specially adapted for use in dentistry.

Mexidol heals damaged gums, improves their blood supply by activating internal processes and blood circulation, and also relieves swelling and inflammation. Licorice extract does not disrupt the normal balance of microflora, acting as an antibacterial agent.

Thanks to this composition, the rinse not only supports, but also prolongs the effect of toothpastes, making them more effective.

Let's watch a short promotional video from the manufacturer of these products:

Consumer Reviews

Milena, 31. I have been using Mexidol Dent Complex paste for 7 years as prescribed by a doctor. It has therapeutic and prophylactic purposes and has a whole range of therapeutic properties: anti-inflammatory, regenerating, immunomodulatory. After using the drug, bacterial plaque does not appear on the teeth for a long time. In addition, I can always rest assured that my breath will be fresh. The only nuance that the manufacturer of the product did not take into account is the lack of advertising. It produces 5 effective lines of toothpastes, but few consumers know about them.

Svetlana, 19 years old. I have been using Mexidil Sensitive paste for a long time and have no intention of changing it to any other drug. In addition to the paste, I also started using the Mexidol series mouthwash. I cannot confirm the magical effect of the products described on the manufacturer’s website, but the pastes really differ from the advertised oral care products. First of all, this is due to the feeling of smooth enamel and clean teeth throughout the day.

Sergey, 36 years old. I decided to try Mexidol Professional paste. I can’t say that the enamel is significantly whitened, but bacterial plaque after hygiene procedures is removed for a long time and does not appear even in the evening. I believe that high-quality teeth whitening can only be done with the help of dentists and no dental care products can cope with this problem.

Toothpastes MEXIDOL dent Professional

A series of hygiene products with an increased amount of the antioxidant Mexidol copes with the most complex problems. All products in the line have a rich composition, which includes chemical and natural components. Formulas actively fight the effects of free radicals and bacteria.

Each remedy has the following effect:

  • reduces bleeding;
  • removes the cause of inflammation;
  • heals wounds, stomatitis;
  • restores blood circulation in tissues.

This is interesting: Biorepair toothpaste line: Plus, Kids

Clinical studies have confirmed the high effectiveness of rinses and toothpastes.

White


Mexidol tooth whitening toothpaste not only successfully lightens the enamel by several tones, but also actively fights carious processes.
The unique formula has a beneficial effect on the oral mucosa, increases saliva production, improves microflora and blocks pathogenic microbes. A product called “Professional White” carefully cleans plaque from each crown. The active substance papain gently penetrates the upper layers of dentin, where it dissolves the dark pigment. Saturation of the enamel with the composition prevents the subsequent formation of deposits and darkening. The pyrophosphate complex repels paint particles between cleanings. The integrity of the structure is not compromised; the enamel layer remains the same. Licorice extract included in the formula protects dentin from caries, relieves inflammation and bleeding.

Average price - 180 rubles.

Attention! The bleach should be used with caution if you have stomatitis or other sores in the mouth.

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