Decasan for inhalation: principle of action and treatment regimen with the drug

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Dekasan for inhalation with a nebulizer is prescribed for the treatment and prevention of colds and viral diseases. It is used as an independent remedy, as well as as part of complex therapy. It is combined with many medications prescribed for the treatment of dry, wet cough, runny nose, and sore throat. Refers to combination products. Produced by YURIA PHARM LLC, Ukraine.

Features of the action

The medication is a combination drug, although according to the instructions it is classified as an antiseptic drug. Intended for topical use. For diseases of the respiratory system it is prescribed by inhalation.

Properties of the medicine:

• antiseptic;
• antiviral;
• anti-inflammatory;
• antifungal;
• antimicrobial;
• antibacterial.

Indications for use are:

• flu;
• acute respiratory infections;
• ARVI;
• COPD;
• bronchitis;
• pneumonia.

The drug can be used at home after consultation with specialists.

Indications for use of the drug Decasan

Pustular bacterial and fungal skin diseases, microbial eczema, purulent-inflammatory lesions of soft tissues (abscess, carbuncle, phlegmon, boil, infected wounds, felon). The drug is prescribed for diseases of the oral cavity (stomatitis, ulcerative necrotizing gingivitis, dystrophic-inflammatory form of periodontal disease I–II degrees in the acute phase). Decasan is also used for lung abscess, bronchiectasis, cystic hypoplasia of the lungs, complicated by suppuration, chronic bronchitis in the acute phase, chronic tonsillitis, tonsillitis, carriage of staphylococci and diphtheria bacilli, nonspecific ulcerative colitis, paraproctitis. For surgical infectious and inflammatory diseases of the abdominal cavity (peritonitis of various etiologies) and in pulmonology, Decasan is used for washing the abdominal and pleural cavities. In urology, the drug is used for urethritis (for instillations into the urethra), balanaposthitis (for baths), prostatitis (for microenemas), cystitis (for instillations into the bladder), and for irrigation of the bladder in the postoperative period. In gynecological practice, Dekasan is used for the treatment of candidiasis of the vaginal mucosa, inflammatory diseases of the external genitalia of microbial etiology, prenatal sanitation of the birth canal, and treatment of postpartum endometritis. Decasan is used to disinfect the skin of medical staff's hands and rubber gloves when examining patients and performing medical procedures, small-scale surgical interventions, pre-sterilization disinfection of medical instruments and diagnostic equipment made of metal, rubber, polymeric materials and glass.

Instructions for inhalation for adults

Treatment begins at the first signs of the disease. The standard dosage is 2 ml at a time. If there is a clear clinical picture, the dose is increased to 5 ml. The duration of inhalation for adults is no more than 20 minutes.

How to breathe Dekasan through a nebulizer

• pour the required amount of the drug into the chamber - 2-5 ml;
• take a comfortable sitting position;
• put on a mask or insert a mouthpiece into your mouth;
• turn on the inhaler;
• inhale through your mouth or nose, hold your breath for 2 seconds, exhale;
• finish inhalation after 15-20 minutes;
• for 1 hour do not drink, do not eat, do not go outside in any weather.

Use the product up to 3 times a day. The duration of the course depends on the severity of the disease. On average, breathing procedures are carried out for 7 days.

Note!

Description of the drug Decasan solution 0.2 mg/ml bottle. 100ml on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Dekasan for inhalation for children

According to the instructions, it is prohibited to use the drug through a nebulizer for children under 12 years of age. However, under the strict supervision of specialists, the medicine is prescribed at an earlier age. Inhalations with Decasan for children last no longer than 15 minutes. On average, the procedure lasts 5 minutes. The regimen and dosage are selected individually. In the first days of the disease, breathing through a nebulizer is allowed 3 times a day. After feeling better, leave 1 procedure in the first half of the day.

Dosage for children

The drug is available in pharmacies without a prescription, but before use you should consult a specialist.

Application

For purulent and fungal skin lesions and infected wounds, the solution is used for rinsing and lotions. To wash the bladder, decamethoxin solution is used after preliminary dilution 1:7 with purified water in an amount of 500–600 ml (7–20 washes per course of treatment). for the treatment of proctitis and ulcerative colitis, a warm solution is administered as an enema, 50–100 ml 2 times a day until the symptoms of exacerbation of the disease are completely eliminated. fistulas with chronic paraproctitis are washed with dekasan daily for 3–4 days.

For lesions of the oral mucosa, it is used in the form of applications of 25–50 ml for 10–15 minutes or rinses (100–150 ml). In the dystrophic-inflammatory form of periodontal disease I–II degrees in the acute phase, irrigation is carried out with a warm solution of pathological gum pockets (50–70 ml) or applications to the gums until the severity of inflammatory phenomena decreases. Patients with candidiasis of the oral mucosa and ulcerative-necrotizing gingivitis are prescribed mouth rinse (100–150 ml) 4 times a day for 5–10 days.

Treatment of candidiasis of the palatine tonsils and chronic tonsillitis is carried out by washing the lacunae of the palatine tonsils (50–75 ml per rinse).

When carrying staphylococcus or diphtheria bacillus, sanitation is carried out by rinsing the pharynx, washing the lacunae, irrigating the nasopharynx and tonsils. Lacunae are washed 3-5 times every other day.

For lung abscess, bronchiectasis, cystic pulmonary hypoplasia complicated by suppuration, chronic bronchitis in the acute phase, Decasan is administered endobronchially:

• through a microtracheostomy - 25–50 ml 1–2 times a day;
• through a transnasal catheter - 5–10 ml once a day;
• by ultrasonic inhalation - 5-10 ml 1-2 times a day;
• using lavage of the tracheobronchial tree - in a volume of 100 ml.

Duration of treatment is 2–4 weeks.

For the treatment of microbial, fungal and trichomonas vaginitis, Decasan is used in the form of douching (50–100 ml of the drug heated to 38 °C 3 times a day). In the same way, prenatal sanitation of the birth canal is carried out once. Treatment of postpartum endometritis is carried out by washing the uterine cavity with a warm preparation (150–200 ml) 2 times a day.

Disinfection of the skin of hands and rubber gloves is carried out by applying 5–10 ml of the drug to a previously washed surface, evenly distributing it over the entire surface to be disinfected for 5 minutes.

Cleaned medical instruments, mouthpieces, tubes and equipment are disinfected by immersion in the solution for 30 minutes.

Treatment of various diseases through a nebulizer

The combined remedy is used for various diseases of the respiratory system. The rules for carrying out the breathing procedure are identical in all cases.

Inhalation of Decasan for cough

The product dries out the mucous membranes and may cause increased coughing. Not recommended for tracheitis, laryngotracheitis with severe attacks of dry cough. Decasan inhalations are prescribed for bronchitis. Breathing procedures should be done in between the administration of other medications. First, mucolytics are used, after 1 hour an antiseptic is administered.

Treatments for a runny nose

Common colds and mild runny nose are treated with steam procedures, sprays, and aerosols . However, if you have a nebulizer at home with the ability to regulate aerosol particles, you can use an antiseptic. The drug is poured into the chamber of the inhaler. Cannulas or a mask are used. Inhale through the nose and exhale through the mouth. Inhalation of Decasan for a runny nose is done for at least 15 minutes. You cannot drink or eat for 30 minutes after the procedure.

For sinusitis

Severe sinusitis is treated comprehensively. Inhalation procedures with a nebulizer are prescribed as an additional method. Antiseptics help destroy pathogenic microflora. When breathing through a nebulizer, the active substances penetrate into the deep parts of the nasal cavity. Cannulas or a mask are used as a nozzle. It is prohibited to carry out treatment in the presence of purulent discharge.

Inhalation with Decasan for laryngitis

For sore throat and sore throat, lozenges and sprays are prescribed. Inhalation treatment with an antiseptic will be effective if an appropriate inhaler is available. The nebulizer should generate large aerosol particles - from 10 units. In this case, the active substances remain on the surface of the larynx. If the device produces small particles, they fall into the lower parts of the respiratory system. A similar situation occurs with inhalation of Decasan for angina. Procedures are strictly prohibited at high temperatures, purulent formations, and fungal infections.

Decasan for inhalation for adenoids

An antiseptic is prescribed as an additional medicine. Treatment begins after confirmation of the diagnosis and consultation with specialists. The drug does not directly affect the cause of the disease and reduces painful symptoms. Breathing procedures with a nebulizer are carried out if an appropriate apparatus is available.

Pharmacological properties of the drug Dekasan

Decamethoxin ([1,10-Decamethylene-(N,N-dimethylmentoxycarbonylmethyl) ammonium dichloride]) is an antiseptic, bis-quaternary ammonium derivative. Concentrating on the cytoplasmic membrane of the microbial cell, it binds to the phosphatidic groups of membrane lipids and disrupts its permeability. Decamethoxin has a pronounced bactericidal effect on staphylococci, streptococci, diphtheria and Pseudomonas aeruginosa, capsular bacteria and a fungicidal effect on yeast fungi, pathogens of epidermophytosis, trichophytosis, microsporia, erythrasma, some types of mold fungi (Aspergillus, penicillium), antiprotozoal effect on Trichomonas, Giardia, viricidal effect on viruses. Highly active against microorganisms resistant to antibiotics (penicillin, chloramphenicol, tetracyclines, streptomycin, monomycin, kanamycin, neomycin, novobiocin, erythromycin, oleandomycin, etc.). The formation of decamethoxin-resistant forms of microorganisms with long-term use occurs slowly. Bacteriostatic (fungistatic) concentrations of the drug are close to its bactericidal (fungicidal), viricidal, antiprotozoal concentrations. During treatment with Decasan, the sensitivity of antibiotic-resistant microorganisms to antibiotics increases. When used externally in the form of rinses or lotions, the drug is practically not absorbed through intact skin, mucous membranes and wound surfaces.

Analogs

The drug has no direct analogues. The active substance is decamethoxin. Means with similar effects:

1. Miramistin;
2. Saline solution;
3. ACC;
4. Dioxidine;
5. Furacilin.

Each medicine has indications and contraindications. The issue of replacing one medication with another should be discussed with a specialist.

Actual information

Decasan (active ingredient - decamethoxin), according to the AT classification, belongs to the group of antiseptic and disinfectant medicines. it has a wide range of antimicrobial, antifungal and antiviral effects due to the ability to interact with phosphate groups of lipids of the cytoplasmic membrane of microorganisms and thus disrupt its permeability and lead to cell destruction. decamethoxin has been used in clinical practice since the 1970s to the present day with consistently high efficiency and has a wide range of indications for use.

Mechanism of action of decamethoxin

As a result of research, it was found that decamethoxin has a bactericidal effect on Pseudomonas aeruginosa, as well as Escherichia coli and Micrococcus lysodeikticus. Due to the fact that decamethoxin is a surfactant, it changes the permeability of the pathogen membrane, leading to the destruction and death of the microorganism, which determines its bactericidal effect (Shchetina VN et al., 1990). The bacteriostatic effect is due to the following mechanisms: inactivation of pathogen exotoxins (Kovalchuk V.P., 2002); reduction of adhesion of pathogenic microorganisms (Zhornyak OI et spivat., 2010).

An in vitro study demonstrated the antifungal effectiveness of decamethoxin against Candida fungi isolated from patients with chronic intestinal diseases. It has also been established that drug resistance to decamethoxin develops very slowly and does not reach a high level (Palii GK, Ivanova SA, 1986).

The effectiveness of Decasan in surgery

A recent clinical study presents the experience of treating 17 patients with cholangitis of various origins using the antiseptic Decasan

. The clinical effectiveness of the drug in the complex therapy of cholangitis was noted, confirmed by the results of a bacteriological study of bile (Aripova NU, Magzumov I.Kh., 2014).

Efficiency of Dekasan

in the treatment of cholangiogenic liver abscess was demonstrated in a clinical study.
The results of treatment of 47 patients with cholangiogenic liver abscess are described. The study proved the effectiveness of sanitation of the abscess cavity with Decasan
(Nychytailo MI et al., 2005),

Dekasan

proposed for use in the complex treatment of infected pancreatic necrosis and its complications (Nichitailo ME, 2010), as well as in the treatment of acute abdominal infectious pathologies of various origins (Fomin PD et al., 2009).

Another study presents the results of complex therapy of 37 patients operated on due to the development of acute abdominal surgical diseases. 22 patients received local therapy with a 0.02% antiseptic solution of decamethoxin. There was a positive effect on the clinical course of diseases, a decrease in the frequency of purulent-septic complications, in particular in patients operated on for acute necrotizing pancreatitis (Konovalov EP, 2004).

The experience of treating 91 patients with peritonitis of various origins using the antiseptic Decasan

. There was marked clinical effectiveness compared to other antiseptics in the complex treatment of peritonitis (Nazirov FN, 2014).

Based on the analysis of research results, it was found that the use of a cationic antiseptic solution (including a 0.02% decamethoxin solution) for sanitation of the abdominal cavity can reduce microbial contamination during sanitation, and also due to this, the frequency of postoperative complications in surgical peritonitis and the number of cases of lethal outcome (Boiko VV et al., 2012).

of Decasan was analyzed in 102 patients

in the treatment of purulent infections of the pararectal area.
According to the data obtained, Decasan
is an effective drug for local therapy of this pathology (Zakharash MP, 2011).

Decamethoxin has also proven itself as an effective drug for preventing suppuration of postoperative wounds after excision of pararectal or coccygeal epithelial cysts (Klimenko AN, Iukhimets AD, 1982).

In one of the clinical studies, the effectiveness of Decasan

in complex therapy of soft tissue necrosis, which resulted in sepsis.
Sepsis is a severe generalized infection usually caused by pathogenic bacteria. It often causes hospitalization and death. The experience gained as a result of the study contributed to a better understanding of the pathomechanisms of this condition, the development of therapy aimed at improving the general condition of patients, and also necessarily including the local use of antibacterial and antiseptic agents in the purulent focus. The study included 192 patients (103 women, 89 men). According to the classification of septic conditions (Chicago, 1991), patients were divided into 3 groups: group 1 - with a local form of infection, group 2 - with systemic inflammatory response syndrome (SIRS, English abbreviation SIRS), which lasts up to 72 hours , 3rd group - with various forms of sepsis, in which SIRS lasts 72 hours or more. In patients whose wounds were treated with Decasan
, a decrease in the severity of pain, tissue swelling, early sanitation of the wound and early appearance of granulation in the wound were noted.
The algorithm for the treatment of sepsis proposed by the authors includes an integrated approach to the treatment of infection through early surgical intervention, intensive supportive care, etiotropic antibacterial therapy and local use of antiseptic therapy with Decasan
.
As a result, it was concluded that Decasan
can be recommended for the disinfection of skin, mucous membranes and wounds in areas of infection caused by bacteria, fungi and protozoa (Fuss J., 2016).

Decamethoxin can also be used to treat burn disease. One clinical study identified the etiology of infectious complications in 71 patients with severe burns. It has been established that the main causative agents of infection in patients with burn disease are S. aureus (35.9%), A. baumannii (25%), P. aeruginosa (12.82%), P. mirabilis (5.12%). Decasan antiseptic solutions has been proven

, miramistin, chlorhexidine. In relation to staphylococcus, high antimicrobial properties of dressing materials, which contain ions of decamethoxin, chlorhexidine, furagin, and silver, have been noted. The clinical effectiveness of the use of materials impregnated with the antimicrobial composition decamethoxin with carboxymethyl starch, hydroxyethylcellulose and polyvinyl acetate, used for the prevention and treatment of infectious-purulent-inflammatory complications in patients with burns, has been proven (Nazarchuk OA, 2016).

Another study presented the results of an observation of 154 patients with open traumatic brain injury. The effectiveness of decamethoxin in patients with purulent-inflammatory complications was confirmed (Pedachenko EG et al., 1992).

Decamethoxin has been widely used as an antiseptic in surgery for many years. Thus, in a clinical study, the advantages of its use in the treatment of purulent processes on the hand (Kravets VP, 1987) and in the complex treatment of complicated forms of paronychia (Palii GK et al., 1988) were demonstrated.

In another study, which involved 286 patients with purulent-inflammatory diseases of the fingers and hands (196 patients (68.5%) with panaritium, 82 (28.7%) with phlegmon and abscesses, 6 (2.1 %) - with boils and 2 (0.7%) - with carbuncles), the effectiveness of the use of decamethoxin as part of the complex treatment of this pathology was confirmed (Fishchenko A. et al., 1992).

The effectiveness of decamethoxin in the treatment of respiratory diseases

Decamethoxin has also demonstrated its effectiveness in otolaryngology. Clinical studies have shown the effectiveness of the use of decamethoxin by inhalation in the treatment of nonspecific diseases of the respiratory tract in children (Kravets AA et al., 1976).

Decamethoxin has demonstrated effectiveness in the treatment of diseases of the oral mucosa (Palii GK et al., 1975), as well as in the treatment of chronic tonsillitis (Zubovich AP, 1978). Studies have determined the sensitivity of pathogenic microflora isolated from children with respiratory tract diseases to decamethoxin (Palii GK, 1974). Decamethoxin can be used for preoperative preparation of patients with nonspecific respiratory diseases (Iukhimets VA, 1985).

Decamethoxin in complex therapy combined with antibiotics is effective in the treatment of purulent-inflammatory diseases of the respiratory system (Radionov BV et al., 1986). The effectiveness of decamethoxin in the complex treatment of chronic bronchitis has also been confirmed by clinical studies. The study involved 72 patients with chronic bronchitis (catarrhal, purulent, and purulent bronchitis complicated by purulent destructive processes). All patients received complex therapy using decamethoxin as a local antibacterial agent. This study found that the inclusion of decamethoxin in complex therapy is effective not only due to its direct antiseptic effect, but also due to the fact that this drug reduces the resistance of microorganisms to antibiotics (Iukhimets VA, Pilipchuk VN, 1990).

Dekasan

has a very wide range of indications for use.
Thus, the use of decamethoxin in the complex therapy of chronic gastritis in combination with biliary tract pathology was proposed (Mokhun' IK et al., 1982). Safety of Decasan established as a result of research
Currently, special attention is paid to the safety of the use of local antiseptics and their effect on the cell cycle, as well as indicators such as DNA fragmentation and apoptosis. In a study on rats, it was demonstrated that Decasan

with higher antimicrobial effectiveness, it is a safer antiseptic than Miramistin. It was demonstrated using flow cytometry that decamethoxin had a minimal proapoptotic effect on rat corneal cells after 2 weeks of drug use. It was also noted that the decrease in cell proliferation was insignificant, as was the increase in nuclear DNA fragmentation. This indicates the absence of the cytotoxic effect of decamethoxin. When studying similar parameters after the use of miramistin, a decrease in the mitotic activity of cells, a significant increase in DNA fragmentation and an increase in apoptosis were revealed, which indicates a higher safety profile of decamethoxin compared to miramistin.

A morphological study was carried out to study the local effect on tissue. Special textiles were impregnated with a mixture of decamethoxin and modified polysaccharides. Based on the results of the study, it was found that there is no toxic effect of antiseptic medical textiles impregnated with decamethoxin on the tissue of the macroorganism. At the same time, a positive effect was observed on the course of regenerative processes, epithelization of wounds, anti-edematous and anti-inflammatory effects (Nazarchuk OA, 2013).

conclusions

Dekasan

- an antiseptic indicated for use in a wide range of infectious and inflammatory diseases.
Its effectiveness and safety have been confirmed in clinical studies. The use of Decasan
for local sanitation of the source of infection can reduce the need for antibiotics, as well as increase the sensitivity of microorganisms to antibiotics when used in combination with
Decasan
.
This drug has no toxic effect. The only contraindication for use is individual intolerance to decamethoxin. There are no restrictions on the use of Decasan
during pregnancy and lactation.
As a surface-active cationic antiseptic, Decasan
is incompatible with soap and other anionic surfactants.

Product description certified by the manufacturer Yuria Pharm

.
Verified by
Likar Turumkulova Irina

Nasal rinsing is an addition to rinsing

Often, diseases of the upper respiratory tract are accompanied by a runny nose, nasal congestion and swelling. To speed up treatment, you can supplement the rinsing with nasal rinsing - this will help relieve swelling and restore the ability to breathe normally.

No more than 20 ml per day is used, and procedures should be carried out no more than two or three times. Once a day is too little. More than three is too many. The pure drug is used only for serious pathologies. For a common runny nose accompanying a sore throat, it is usually diluted in a ratio of 1:7 with filtered water or saline. Rinsing is possible in a lightweight version, which requires a soft rubber bulb - the smallest of those that can be bought at a pharmacy. You should:

• blow your nose - thoroughly, so as to completely clear the nasal passages, and if this is not possible, use vasoconstrictor drops;
• take the preparation into the bulb and lubricate its tip with Vaseline;
• carefully insert the nose of the pear into your nose, tilt your head back slightly and press slowly, smoothly - as a result, the water should go up the nostril and exit through the other nostril;
• Repeat the entire procedure from the second nostril.

• blow your nose - manually or using vasoconstrictor drops;
• take the drug into your palm;
• bend your head and suck in the contents of your palm through one nostril.

If everything goes right, Dekasan will pass through the nostril and out the other, flushing out bacteria and relieving swelling.

It is important to remember that you can only rinse children’s noses with the first method.

Despite all its benefits, using Dekasan at home as the only drug for the treatment of sore throat, laryngitis or tonsillitis is a bad idea. Treatment must be comprehensive. Only then will it bear fruit.

Interaction

The main active ingredient has cationic surfactant properties , which partly determines its therapeutic effect, and therefore is not compatible with pharmaceuticals that exhibit anionic activity (for example, soap).

A non-drug interaction is an increase in the sensitivity of resistant strains of microorganisms to various types of antibiotics , which implies abundant use of the drug in surgical practice.

Dekasan price, where to buy

The price of Dekasan in the Russian Federation fluctuates around 80 rubles, but finding it in pharmacy kiosks is quite a difficult task.

In Ukraine, a solution of a pharmaceutical drug can be purchased starting from 25 hryvnia, and nebulas for a modern inhaler are described at a price of 30 hryvnia for a cardboard package of 10 pieces.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

LuxPharma* special offer

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