Features of using the drug "Vinilin" for stomatitis

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Polivinox improves tissue restoration and healing, providing an additional anti-inflammatory effect. It also demonstrates local antimicrobial and enveloping effects.

Pharmacokinetics

The antiseptic effect is caused by the ability of the drug to dehydrate microbial cells, coagulating protein and thereby provoking the death of microbes. As a consequence, restoration occurs by replacing the area of ​​necrosis with connective or specific tissue.

When used externally, it promotes epithelization, wound cleansing, and tissue regeneration.

CLINICAL STUDY REPORT

STUDYING THE EFFECTIVENESS OF APPLICATION

PREPARATION "VINYLIN" IN AEROSOL PACKAGING

FOR TREATMENT OF WOUNDS.

Keywords

: burns, wounds, ulcers, bedsores, Vinilin, Shostakovsky Balm, dressings, aerosol.

In difficult modern socio-economic conditions, against the backdrop of frequent industrial and transport accidents, terrorist attacks and local military conflicts, the importance of the problem of burn injuries is increasing (Azolov V.V., Zhegalov V.A., Dmitriev G.I., 2004). At the same time, a significant role in the course and outcome of thermal injury, the development of infectious complications of burn disease and the recovery time of patients is given to local conservative treatment of burnt patients. In Russia, for local treatment of burn wounds, regardless of the depth of the burn lesion and the stage of the wound process, due to accessibility and low economic costs, gauze dressings with antiseptic solutions (usually furatsilin and chlorhexidine) or hydrophilic ointments (mainly Levomekol) are most often used ). Considering the possible polymorphism of burn wounds, especially extensive ones, when, along with healing superficial burns, there are deep wounds made by granulations, with remnants of necrosis and at the same time marginal and islet epithelization, the use of combined drugs with a multidirectional therapeutic effect on the wound process is justified. For these purposes, multicomponent ointments on a hydrophilic basis have proven themselves well. However, when using them, there is overdrying of the surface and tissues of the wound and an insufficient stimulating effect on repair (O.A. Kudzoev, 1995), and the existing side effects of these drugs are often associated with the antibacterial drugs they contain.

Of great interest is the appearance on the modern market of new drugs that have a multi-purpose effect and at the same time do not contain antibiotics and sulfonamides.

The ultimate goal of wound treatment is to heal as quickly as possible. A burn wound is distinguished by its unique healing processes. In this regard, in the tactics of managing burn patients, an important place is occupied by local therapy of burn disease, timely closure of the wound surface to reduce its infection, intoxication, and accelerate the time of epithelization of the burn wound. It is important to divide burns into superficial ones, which, if the course of the wound process is favorable, can heal on their own, and deep ones, in which the germ layer of the skin is damaged and, therefore, require surgical treatment. For any depth of lesion, local wound treatment is of great importance. For superficial burns, conservative treatment ensures complete healing. For deep burns, local treatment is used to prepare wounds for surgery and create conditions for the engraftment of transplanted grafts, healing of donor wounds, improving the quality of scars, and preventing contractures.

Characterizing the modern requirements for antiseptics, prof. Rufanov in the “Textbook of General Surgery” writes: “Drugs must have the following properties: be bactericidal, not have a harmful effect on the cells and tissues of the body, not lose their effect when in contact with living tissues, not be volatile, be easy to use, cost they should be low, allowing widespread distribution.” Recently, a huge number of different drugs and forms have been used to treat burn wounds, however, a large number of allergic reactions and the emergence of antibiotic-resistant forms of pathogenic microorganisms makes us recall long-developed drugs, whose clinical effectiveness has been tested by time. One of these drugs is Vinilin.

VINYLINE. Shostakovsky balm (Vinylinum. Balzamum Schostakowsky). Polyvinylbutyl ether. Thick viscous liquid of light yellow color with a specific odor. Practically insoluble in water. Mixes with chloroform, ether, vegetable oils.

Research problem

: to study the effectiveness of using vinylin in the form of an aerosol in the local treatment of burns and long-term non-healing wounds.

Materials and methods

: the results of treatment of 33 patients with thermal injury and its consequences who were hospitalized in the Republican Burn Center were studied. All patients were men aged from 18 to 67 years (average age 42.6 years), without concomitant pathology in the stage of decompensation. The patients were divided into 3 groups - the first group of 20 patients with burns of II-IIIA degree of various etiologies with an area of ​​\u200b\u200bfrom 10 to 35% of the body surface, the second group of 10 people with burns of IIIAB-IV degree on an area from 7 to 40% of the body surface, in the third group of 3 people with long-term non-healing pressure wounds.

After autodermoplasty, patients in the second group applied bandages with vinylin to mesh grafts and treated donor wounds with vinylin.

Method of application: wounds on an area of ​​up to 15% of the body surface were irrigated with vinylin from an aerosol can, after which gauze bandages up to 3-4 layers thick were applied (including fixing bandages). The dressings were changed as the wound discharge became contaminated, but not more than 3 times a week. Dressings were applied to donor wounds once.

Control methods

: carried out on the basis of visual monitoring of the course of the wound process, assessment of the amount and nature of wound discharge, bleeding of wounds, timing of transition to another phase of the wound process, timing of the onset of epithelialization, in case of deep damage - readiness of wounds for autodermoplasty, engraftment of grafts and healing of donor wounds, all patients underwent microbiological examination of wound discharge. The pain reaction directly during dressing was assessed by patients subjectively according to the intensity of pain on a 10-point scale, where 0 is the absence of pain, and 10 is the maximum pain. Comparisons were made with neighboring wound areas, similar in depth of the lesion, and with the average performance of patients in the burn department who were treated for burn wounds using traditional methods. The comparison groups were comparable in depth, lesion area, gender and age.

results

First group. 20 patients with superficial burns of various etiologies. Treatment began within 1 to 7 days from the moment of injury. Before treatment, burn wounds after removal of the exfoliated epidermis had a moist, pink surface, whitish in some areas. In patients admitted 3-5 days after a wound injury with scanty purulent discharge, in places fibrin deposits, the formation of foci of thin brownish scab. 12 people had a zone of hyperemia up to 3 cm wide around the wounds, moderate perifocal edema (especially in the lower extremities). In patients, St.aureus was cultured from wound discharge in 16 patients, Ps.aeruginosa in 14 patients, and Proteus vulgaris in 2 patients. The initial level of infection did not exceed 1000 CFU/cm2. After taking cultures and thoroughly cleaning the wounds, bandages with vinylin were applied. For 11 people in this group, the bandages were not removed until the wounds had completely healed; for seven, the bandages were changed twice; for two, the bandages had to be changed three times. In all patients, the wounds healed without complications.

The average healing time for wounds under bandages with vinylin was 12.7 days from the moment of injury. In neighboring areas treated with levomekol, the average wound healing time was 12.9 days, and the dressings had to be changed 3-4 times a week. In the control group, the wound healing period was 14.3 days, which correlates with literature data.

Assessing the severity of pain

main and control groups for the treatment of superficial burns

In the second group

Vinyl bandages were applied to deep lesions. Vinyl dressings were applied to wounds covering up to 10% of the body surface. Under bandages with vinylin, the scab was softer, and perifocal inflammation was less pronounced. St.aureus and Ps.aeruginosa were cultured from wound discharge, and the lack of sensitivity of microorganisms to most antibiotics was noted. Before applying dressings, the level of contamination reached 104 CFU/cm2; after the start of treatment, the wounds were cleaned, the amount of purulent discharge decreased, and granulations appeared.

Table

Changes in the number of microorganisms in the discharge of burn wounds under the influence of local therapy.

From the data presented in the table and graph it is clear that in terms of bactericidal activity, vinylin is slightly superior to chlorhexidine, but inferior to levomekol. It was noted that under the influence of vinylin the granulations were brighter and more even. It should be considered a positive thing that changing dressings with vinylin was less painful than dressings with levomekol and much less painful than wet-dry dressings. There were no significant differences in the time it took to prepare wounds for surgery, either compared to control sites or compared to the control group.

In the postoperative period, bandages with vinylin were applied to mesh grafts with an area of ​​up to 5% of the body surface and for the same patients on donor wounds with an area of ​​up to 3% of the body surface. Vinylin was applied directly to the transplanted autodermal grafts, 3.5 mm thick, perforated in a Collins type apparatus with a perforation ratio of 1:3 and 1:4, then the wounds were covered with 3-4 layers of gauze. The first dressing was performed on days 2-3 after surgery, and subsequently every 2-3 days. In the absence of significant exudation, the bandage remained on the wound for up to 5 days. During the first dressing of wounds covered with wet-dry gauze dressings, in all cases the dressings stuck to the wound; they had to be removed very carefully, which sharply increased the time spent on dressing; in all cases, damage to the young epithelium occurred, in places the grafts were torn from the bed, which was accompanied by capillary bleeding, in 23.5% of cases foci of graft lysis appeared.

All patients had graft engraftment on 90-95% of the area, which is regarded as a good result. The time for completion of epithelization in the cells ranged from 7 to 13 days. The pain intensity score 30 minutes after changing dressings on mesh grafts was 3.3±0.6 in areas where the wounds were covered with vinylin and 5.7±0.4 in wounds with wet-dry dressings.

On the donor sites, the wounds healed in 11.7 days, which is 1.4 days earlier than on the control sites. Particularly noteworthy is the fact that wound healing in all cases proceeded without peripheral inflammation and pain in the early postoperative period was much less than with the traditional method of wound management, as the bandage retained its elasticity.

After applying the first bandage, almost all patients noted a slight burning sensation in the wound, which lasted for 15-20 minutes. Subsequent dressings were almost painless. Patients quickly got used to the specific smell of vinylin, and since the drug acts as a deodorant

, then its smell became even pleasant for them.
Already upon removal of the first bandage, most patients observed clearing of the wound from necrotic tissue and the appearance of healthy granulations
where they were poorly expressed, flaccid, with a cyanotic tint.

After the second and subsequent dressings, it was possible to state: rapid growth of granulation tissue of a bright red color, disappearance of swelling, rapid epithalization from the edges of the wound, a sharp decrease in discharge .

The third group included 3 patients with long-term non-healing pressure wounds. Wounds with a diameter of 2 to 5 cm located in the heel areas were treated with levomekol, furatsilin ointment, dressings with a chlorhexidine solution 1:2000 for 34-45 days. Before starting treatment with vinylin, wounds with scanty purulent discharge and slight hyperemia of the edges. The edges of the wounds are dense, lumpy, slightly undermined, the bottom is covered with coarsely lumpy dense scar granulations. Before applying vinylin, hypertrophic layers of the epidermis were removed from the edges of the wounds, the scarred granulations were scraped out with a Volkmann spoon, and after careful cleaning of the wounds, bandages with vinylin were applied. The dressings were changed daily. After 2 days, a significant decrease in the amount of wound discharge was noted; bright, fine-grained granulations and a rim of epithelization along the edges of the wounds appeared. The dressings were almost painless, without bleeding.

After 10 days, the first wound healed and a delicate layer of young epidermis formed. The edges of the healed wound were elastic, without hyperkeratosis. The second wound healed after 14 days, the third patient was discharged for family reasons 17 days after the start of treatment with a clinical picture of pronounced positive dynamics - the wound decreased in size to 1x1cm, cleaned up, and was actively healing.

The discussion of the results:

The study showed that the use of vinylin is most effective in the treatment of II-III A degree burns. The use of vinylin can reduce pain during dressings, reduce the number of dressings and wound healing time. In some cases, 1-2 changes of dressings were sufficient for complete wound healing.

In the treatment of deep burns of various etiologies, the use of vinylin did not have a significant effect on the time it took to prepare wounds for surgery, but dressings were less painful. The use of vinylin on mesh grafts and donor wounds contributed to a significant reduction in pain in the postoperative period, accelerated wound healing, and prevented lysis of grafts.

The use of vinylin was well tolerated by patients; no irritation or allergic reactions were noted. At the same time, it should be noted that the drug has low bactericidal activity. Vinilin does not have a hemostatic effect, so careful hemostasis was required during dressings.

Thus, the main indications for the use of vinylin are:

1. atraumatic and painless treatment of superficial burns;

2. for IIIB-IV degree burns - postoperative management of mesh grafts and donor wounds;

3. treatment of bedsores, long-term non-healing wounds, cicatricial trophic ulcers.

Vinilin is a fairly effective treatment for wounds both in the hospital and on an outpatient basis.

The economic efficiency of using vinylin is to reduce the number of dressings and save dressing materials, and to shorten the treatment time for patients.

CONCLUSIONS

Vinylin balm is an effective remedy; it is recommended for burns of various degrees in the form of dressings or open treatment.

The dressings are easily removed without causing pain or injuring the granulating, epithelial surface.

The balm has deodorizing properties

It is not a toxic substance and does not cause side effects in the body, no matter in what quantities it is used, which makes it possible to use it for extensive burns.

Vinilin allows you to speed up the healing of superficial burns and reduce the time required to prepare stage IIIB – IV burns for autodermoplasty.

The use of Vinilin allows you to accelerate the healing of donor wounds and avoid inflammatory changes.

Wounds after treatment with vinylin heal with the subsequent formation of a soft, elastic, non-tightening scar.

Vinilin’s ability to actively mobilize the body’s defenses, accelerate and enhance reactive and regenerative processes in the tissues and cells of the wound has been noted, thanks to which Vinilin

effective in the treatment of not only fresh, but also long-term non-healing wounds, trophic ulcers, bedsores.

Thus, based on the totality of medical characteristics and consumer qualities, the drug Vinilin in aerosol packaging is an effective remedy for the treatment of burns and long-term non-healing wounds, both in a hospital and on an outpatient basis.

Notes: although it is more convenient and faster to apply vinylin to a wound from an aerosol package than from a bottle, the jet does not disperse well, so the drug is applied in a very narrow strip; modification of the sprayer is required.

REFERENCES

Alekseev A. Treatment of severely burned patients: problems and successes. Doctor No. 4, 1998, p. 32–33.

Arev T.Ya. Reliable, probable and doubtful in modern ideas about burn disease. Bulletin of Surgery named after Grekov, 1967, v. 99, no. 7, p. 95-101.

Rudovsky V., Nazilovsky V., Zitkevich V., Zinkevich K. Theory and practice of treating burns, M., Medicine, 1980.

Tyurnikov Yu.I., Evteev A.A. “Methods of active surgical preparation of deep burns for plastic closure”, collection of abstracts of the international conference “Plastic surgery for burns and wounds”, Moscow, December 5-7, 1994, pp. 62-4.

Evteev A.A., Tyurnikov Yu.I. “Tangential excision of granulating wounds (TIGR), as a method of surgical preparation of deep burns for autodermoplasty”, ibid., p. 30-2.

Povstyanoy N.E., Kovalenko O.N. “The choice of methods of skin grafting in the early surgical treatment of burns,” collection of abstracts of the international congress “Combustiology at the turn of the century,” Moscow, October 9-12, 2000, p. 149.

Menzul V.A., Grishkevich V.M., Brey, ibid., p.146.

Collection of scientific papers of the I Congress of Combustiologists of Russia, Moscow, October 17-21, 2005.

Malyutina N.B., Tyurnikov Yu.I., Evteev A.A., Kalyanov A.V. “Experience in using a coating of lyophilized pig skin for the treatment of patients with extensive deep burns,” ibid., pp. 138-9.

Evteev A.A., Tyurnikov Yu.I. et al. “Regression of skin grafts”, collection of abstracts of the scientific conference “Current problems of traumatology and orthopedics”, part 2 “Thermal injury”, Nizhny Novgorod, 2001, pp. 95-6.

Demenko S.Yu. et al. “Complex treatment of late lysis of newly formed epidermis”, collection of abstracts of the international conference dedicated to the 70th anniversary of the Research Institute of Emergency Medicine named after. I.I. Dzhanelidze and the 55th anniversary of the burn center, St. Petersburg, June 27-29, 2002, pp. 138-139.

Evteev A.A., Tyurnikov Yu.I. et al., “Verbal-numeric scale of autodermoplasty results”, ibid., pp. 265-8.

Vikhriev B.S., Lomonosov A.S., Volchek I.A. Immunological prediction of early lysis of autodermal grafts in burned patients. Journal of Surgery named after Grekov, 1984, vol. 133, No. 12,48-9.

Matsumura H., Meyer N.A., Mann R., Heinbach D.M. “Melting-Graft – Wound Syndrome.”
JBCR, 1998, 19, 4, p.292-5. University of Washington Burn Center Seattle, WA. Head of the Research Center NNIITO, Professor Peretyagin S.P. Responsible executive Head of the 1st burn department, researcher Struchkov A.A. Signature of Peretyagin S.P. and Struchkova A.A. I ASSURE Scientific Secretary of NNIITO, kmn Marsak G.A.

Instructions for use of Vinilin (Shostakovsky balm) (Method and dosage)

The drug is allowed to be used externally, orally and rectally.

Vinylin, instructions for use

Externally: ointment (with the drug in the composition), balm in pure form or in the form of oil solutions is applied to napkins and with their help the affected area is directly treated.

Orally Vinilin (Shostakovsky balm) is taken once a day 5 hours after an evening meal (a small dinner at 6 pm and medication at 11 pm are recommended):

• for peptic ulcers, take 1 teaspoon of liquid on the first day, in the subsequent days of treatment take 1 dessert spoon per day (the course of treatment averages 17–20 days);
• for gastritis with increased secretion and heartburn, it is recommended to take 1 teaspoon of liquid on the 1st day, and then 1 dessert spoon every other day for 10–12 days.

into the rectum (via a rectoscope ) at a time for 3–9 days.

Vinylin for stomatitis is used to treat ulcers, for which the balm is applied to a cotton swab and the affected area is treated with it up to three times a day. Within 30 minutes after such a procedure, it is forbidden to drink or eat.

Vinilin for sore throat

It is allowed to use the drug for sore throat , treating the throat with a Vinyl-soaked cloth up to 4 times a day. However, it is worth noting that the effectiveness of the described treatment has not been proven.

Contraindications for the drug Vinilin

• Children's age up to 14 years.
• Kidney and liver diseases.
• Individual intolerance to some components of the drug.

But very often dentists prescribe a balm for stomatitis for children who have not yet turned 14 years old. It is important that the child is not able to swallow the medicine. In addition, you need to carefully monitor the baby's condition: if you see the slightest rash, stop using the drug and show the child to the doctor.

Keep in mind that Vinilin can only eliminate the unpleasant manifestations of stomatitis; the causes of the development of the disease are hidden deeper. It is for this reason that you cannot treat with balm yourself. It is better to seek help from a dentist and pediatrician.

Features of use

Despite contraindications for the use of ointment before the age of 14, dentists often prescribe it for the treatment of stomatitis in children. You just need to follow the dosage and all the doctor’s recommendations.

The ointment should be used with extreme caution in children who are prone to allergies. In case of the slightest manifestation of an allergic reaction, you must stop using the drug, even if it copes well with the symptoms of the disease.

Often ointment is prescribed for the treatment of candidal stomatitis in infants. In this case, it is imperative to monitor the condition of the baby and follow the dosage.

Analogs

Level 4 ATC code matches: Naftalan oil
Suporon

Naftaderm

Hydrogen peroxide

Potassium permangantsovka

Iodoform

Pantocide

Diamond green

Ectericide

Salicylic-zinc paste

Elekasol

Salicylic-Zinc ointment

Formalin

Formagel

Aseptolin

Xeroform

Vitaon

Olazol

Formidron

Octenisept

Aekol, Actovegin, Solcoseryl, Dexpanthenol, Alantan Plus, Happyderm Forte.

How to treat ulcerative stomatitis?

Effective treatment of Vincent's ulcerative stomatitis should be comprehensive:

1. Anesthesia – performed to relieve acute pain. Experts recommend applying compresses with pain-relieving solutions.
2. Removing rashes. This should only be done by a doctor. First, compresses with a softening composition are applied to the ulcers, after which the crusts are gradually cleared from the surface of the mucosa, treating with hydrogen peroxide, potassium permanganate, chlorhexidine, etc.
3. General treatment. It involves taking antihistamines that relieve general tissue irritation and the inflammatory process. For severe manifestations and complex symptoms, antibiotic therapy is prescribed. It is also recommended to take a course of vitamin therapy.
4. Sanitation of the oral cavity. Effective treatment of caries, removal of pathological teeth. For wound healing, treatment with keratoplasty preparations, gels and ointments is recommended.

Price of Vinilin (Shostakovsky balm), where to buy

The price of Vinilin in a 50 g bottle in Russia is 190-220 rubles. In different regions of Russia, prices are almost the same, although in Chelyabinsk this form of the drug can be purchased for 155 rubles.

Vinyl in a 50 g bottle, which resembles an ointment in consistency and is often used for stomatitis, wounds, burns and other lesions in Ukraine, can be bought for an average of 28-35 hryvnia.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

ZdravCity

• Vinyline liquid d/v.
  and adv. approx. fl 100g No. 1AO Tatkhimfarmpreparaty 152 rub.order
• Vinilin (Shostakovsky balm) 100g Tula Pharmaceutical Factory LLC

  RUB 153 order

• Vinilin (Shostakovsky balm) 50g JSC KHIMREAKTIVKOMPLEKT FACTORY

  119 RUR order

Pharmacy Dialogue

• Vinilin (flask 50g) Tula FF

  79 RUR order

• Vinilin (flask 100g) Tula FF

  RUB 149 order

• Vinilin (flask 50g) Khimreaktivkomplekt plant

  103 rub. order

• Vinilin (flask 50g) Usolye-Sibirsky Chemical Physics Complex

  62 RUR order

• Vinilin (bottle 100g) Khimreaktivkomplekt Plant

  162 RUR order

show more

Pharmacy24

• Vinyline 100 g (Shostakovsky balm) solution PAT "Vitamin" Ukraine
  95 UAH.order
• Vinyl balm Shostakovsky 50 g PAT "Vitamin" Ukraine

  52 UAH order

The main symptoms of Vincent's stomatitis

The most common symptom is the presence of numerous ulcerations in the oral cavity: on the inside of the cheeks, lips, palate and other areas. Other manifestations may vary, depending on the degree of the disease.

Symptoms of mild ulcerative stomatitis:

• increased salivation;
• pain in the mouth, especially when palpating soft tissues;
• bleeding gums, especially when eating and brushing teeth;
• swelling of the gums.

Manifestations of ulcerative necrotic stomatitis of the middle stage.

• wounds with necrotic crusts;
• bleeding gums;
• unpleasant odor;
• pus secreted from periodontal pockets;
• enlarged and painful lymph nodes;
• muscle weakness and loss of strength;
• temperature increase;
• loss of appetite.

Symptoms of ulcerative stomatitis of complex stage.

• severe weakness;
• stomach ache;
• nausea;
• vomit;
• increased body temperature;
• deep ulcers that can reach the bone tissue.

If these symptoms appear, you must immediately consult a dentist! The disease is treated exclusively under the supervision of an experienced doctor - treatment at home can significantly aggravate the situation.

Properties and release form

Vinyl is a viscous, thick liquid with a peculiar aroma. The balm has a light yellow tint. It is insoluble in water, but is miscible with chloroform, ether, liquid paraffin, ethyl alcohol and oil. Vinyl will not dry out or thicken when exposed to air.

The product is available in dark bottles of 50 g and 100 g. They are packaged in cardboard boxes and supplied with instructions. The drug is available in the form of gelatin capsules.

Instructions

Vinilin balm is a drug with antimicrobial and anti-inflammatory effects.
The drug is famous for its enveloping ability, which has a beneficial effect on the healing of wound, burn and ulcer surfaces with a cleansing effect. In addition, the balm has the effect of local anesthesia. Instructions for the balm are included in the form of a leaflet and are briefly printed on the cardboard packaging.

Form, composition, packaging

The medicinal product in the form of Vinilin balm is a liquid, thick and viscous. The consistency is similar to ointment. The color is light yellow. The smell is sharp and specific. The drug does not dissolve in water. Alcohols (butyl, isoamyl), oils, ethyl ether, liquid paraffin and chloroform are excellent for mixing.

Left in the open air, the balm does not thicken or dry out.

The active substance is (vinyline) polyvinox.

The drug is dispensed in dark glass bottles of 100 or 50 grams, each in its own cardboard pack.

Large batches of bottles with balm, 50 grams each. placed in thick cardboard boxes of two, four, five, six, eight, ten or twelve dozen.

Storage period and conditions

The shelf life of the balm can be considered five years of storage in proper conditions. The drug package must be closed. The containment area is darkened. The optimal air temperature is 25 degrees.

Pharmacology

Shostakovsky's balm called Vinilin has an antimicrobial, anti-inflammatory and epithelial regenerating effect. Locally it has an enveloping effect.

The medicine dehydrates the microbial cell, having an antiseptic effect and coagulates the protein, which leads to the death of the pathogen. Being replaced by connective tissue, the necrotic area is restored.

When used externally, it epithelizes and regenerates tissue in the area of ​​damage and cleanses wound surfaces.

Pharmacokinetics

The instructions do not contain information about the pharmacokinetic properties of the drug.

Treatment

During periods of moderate to mild exacerbation, outpatient treatment is indicated for patients. It includes a diet (No. 4-a in medical terminology), when reducing the inflammatory process, diet No. 4-b is recommended, and during remission - No. 4c, and finally - a simple diet. If the exacerbation is too severe, the patient may be “fed” through a vein.

The main medications prescribed for colitis

– these are drugs of the 5-aminosalicylic acid group (mesalazine and sulfasalazine). They provide an anti-inflammatory effect and heal the inflamed mucous membrane of the colon. But, it should be remembered that sulfasalazine has more side effects than mesalazine.

Hormonal drugs

prescribed if the previous treatment option was ineffective.

Biological drugs

such as Remicade and Humira, the doctor prescribes for hormone-resistant forms of colitis.