Description of the drug
Pentalgin has a single release form - tablets. They can be of different colors: bluish, yellow, cream. Each tablet is divided in half by an indented line and contains an embossed name. The package may contain 10 or 12 doses of Pentalgin.
Reviews from those who took Pentalgin for toothache are mostly positive
Patients who have dealt with acute toothache usually praise Pentalgin, sold by prescription. How is the drug effective?
Typically, the drug is prescribed to the patient for the complex treatment of various conditions associated with fairly severe pain:
- Neuralgia
- Migraines
- Muscle spasms
- After injuries and operations
The effective action of the tablet's components encourages dentists to prescribe Pentalgin for severe toothache.
Pentalgin is a combination of 5 components that actively act on the painful area:
- Metamizole sodium (analgin) – lowers body temperature, relieves inflammation, eliminates pain
- Paracetamol - has an effect similar to that of analgin
- Caffeine – prevents migraines, improves mood, stimulates the central nervous system and prevents collapse
- Phenobarbital - has a selective inhibitory effect on the nervous system, thereby calming pain receptors and relaxing the body
- Codeine – has a calming effect on the body and relieves pain
It is the presence of codeine in tablets that forces pharmacists to refuse to sell it without a prescription. What is codeine and why is it dangerous for the human body?
Antispasmodics for headaches
A common cause of headaches is cerebral vasospasm. In this case, myotropic antispasmodics help relieve headaches:
- No-shpa (drotaverine);
- dibazole;
- papaverine;
- revalgin;
- dexalgin.
Neurotropic antispasmodics block the transmission of nerve impulses to smooth muscles, causing spasmodic vessels to dilate. Neurotropic vasodilators include:
- buscopan;
- scopolamine;
- aprofen;
- ganglefen;
- hyoscine;
- ganglefen;
- Arpenal.
Does spasmalgon help with headaches? The drug has a pronounced antispasmodic effect and eliminates headaches caused by vasospasm. Baralgin helps many patients against headaches. Mydocalm can help with headaches if the cause of the pain is muscle spasm.
Panadol belongs to the group of non-selective non-steroidal anti-inflammatory drugs. It relieves headaches thanks to the analgesic effect of the main active agent - paracetamol. The drug is effective for headaches caused by fever.
Pentalgin tablets No. 12
Indications
- mild and moderate pain syndrome of various origins (including pain in joints, muscles, radiculitis, algodismenorrhea, neuralgia, headache, migraine, toothache);
- fevers, colds and other diseases accompanied by pain and inflammation.
Directions for use and doses
Pentalgin is taken orally, 1 tablet 1-3 times a day.
The maximum daily dose is 4 tablets.
The duration of treatment is no more than 3 days as an antipyretic and no more than 5 days as an analgesic.
Continuation of treatment with the drug is possible only after consultation with a doctor.
special instructions
Avoid simultaneous use of Pentalgin with other drugs containing paracetamol and/or other non-steroidal anti-inflammatory drugs, as well as with drugs to relieve the symptoms of colds, flu and nasal congestion.
When using the drug for more than 5–7 days, peripheral blood counts and the functional state of the liver should be monitored.
Paracetamol distorts the results of laboratory tests of glucose and uric acid in blood plasma.
If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study. Please note that naproxen increases bleeding time.
The effect of caffeine on the central nervous system depends on the type of nervous system and can be manifested by both excitation and inhibition of higher nervous activity.
During the treatment period you should not drink alcoholic beverages.
In some cases, a decrease in concentration and speed of psychomotor reactions is possible, therefore, during the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Compound
1 tablet contains: paracetamol 325 mg, naproxen 100 mg, caffeine 50 mg, drotaverine hydrochloride - 40 mg, pheniramine maleate - 10 mg; excipients: microcrystalline cellulose, potato starch, croscarmellose sodium, hyprolose (hydroxypropylcellulose (Klucel EF)), citric acid monohydrate, butylated hydroxytoluene (E 321), magnesium stearate, talc, quinoline yellow dye (E 104), indigo carmine (E 132).
Contraindications
- severe liver failure;
- severe renal failure;
- peptic ulcer of the stomach and duodenum in the acute phase;
- bronchial asthma;
- bronchospasm;
- anemia, leukopenia;
- conditions accompanied by respiratory depression;
- traumatic brain injury;
- severe arterial hypertension;
- acute myocardial infarction;
- arrhythmias;
- alcohol intoxication;
- glaucoma; glucose-6-phosphate dehydrogenase deficiency;
- children under 12 years of age;
- hypersensitivity to the components of the drug.
The drug should be used with caution in mild to moderate arterial hypertension, gastric and/or duodenal ulcers in remission, as well as in elderly patients.
Use during pregnancy and breastfeeding
The use of the drug is contraindicated during pregnancy and lactation (breastfeeding).
Side effects
Allergic reactions: skin rash, itching, urticaria, angioedema;
From the hematopoietic organs: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia;
From the nervous system: agitation, anxiety, increased reflexes, tremor, headache, sleep disturbances, dizziness, decreased concentration;
From the cardiovascular system: palpitations, arrhythmias, increased blood pressure;
From the digestive system: erosive and ulcerative lesions of the gastrointestinal tract, nausea, vomiting, epigastric discomfort, abdominal pain, constipation, impaired liver function;
From the urinary system: impaired renal function;
From the senses: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma;
Other: dermatitis, tachypnea (increased breathing).
Overdose
Symptoms: nausea, vomiting, gastralgia, drowsiness, tachycardia, cardiac arrhythmias, delirium, weakness, respiratory depression.
Treatment: induction of vomiting, gastric lavage through a tube, administration of adsorbents (activated carbon), symptomatic therapy aimed at maintaining vital functions.
Storage conditions
Store in a dry place, protected from light, at a temperature not exceeding 25°C.
Best before date
1 year.
pharmachologic effect
The combined drug has analgesic, antipyretic and anti-inflammatory effects.
Drotaverine - has a myotropic antispasmodic effect due to inhibition of phosphodiesterase IV, acts on smooth muscles in the gastrointestinal tract, biliary tract, genitourinary and vascular systems.
Pheniramine is an H1-histamine receptor blocker. It has an antispasmodic and mild sedative effect, reduces exudation, and also enhances the analgesic effect of paracetamol and naproxen.
Paracetamol is a non-narcotic analgesic that has an antipyretic and analgesic effect due to the blockade of cyclooxygenase in the central nervous system and its effect on the centers of pain and thermoregulation.
Naproxen is a non-steroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic effects associated with non-selective inhibition of the activity of cyclooxygenase, which regulates the synthesis of prostaglandins.
Caffeine - causes dilation of blood vessels in skeletal muscles, heart, kidneys; increases mental and physical performance, helps eliminate fatigue and drowsiness; increases the permeability of histohematic barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. It has a tonic effect on the blood vessels of the brain.
Drug interactions
With the simultaneous use of drugs that have a depressant effect on the central nervous system (including sedatives and tranquilizers), the severity of the sedative effect and inhibitory effect on the respiratory center is likely to increase.
Strengthens the effect of ethanol on the psychomotor reaction. Metamizole sodium reduces the concentration of cyclosporine. Metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin from protein binding, increases their activity.
Tricyclic antidepressants, oral contraceptives, and allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity.
Concomitant use of the drug with other non-narcotic analgesics may lead to increased toxic effects.
Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effect of metamizole.
Contraindications
Pentalgin has special precautions that must be taken into account when choosing this remedy for the treatment of tooth pain. The drug is prohibited for the following conditions:
- Presence of diabetes mellitus;
- Open ulcers and bleeding in the gastrointestinal tract;
- Problems with the heart and vascular system;
- Acute liver and kidney problems;
- Hepatitis of viral etiology;
- Tendency to epileptic seizures;
- Old age of patients;
- Childhood and early adolescence;
- Condition after any heart surgery;
- Tachycardia or other heart rhythm disturbances;
- Pregnancy and lactation period;
- Frequent increase in pressure in the arteries;
- Individual negative reactions of the body.
Side effects and overdose
At the very beginning of treatment for dental pain with Pentalgin, the patient should listen to his condition. If at least one of the following effects is noticed, you should stop taking the drug. Consultation with a doctor is recommended.
What can Pentalgin cause in a patient?
- Allergy in any form: hives, skin rashes, swelling and itching
- Disturbances in the composition of the blood, its dangerous conditions
- Strange reactions of the central nervous system that have not been observed before: increased anxiety, sleep disturbances, decreased attentiveness
- Malfunction of the heart and blood vessels, which is expressed in increased heart rate, increased blood pressure, and interruptions in the heart
- Discomfort in the gastrointestinal tract: vomiting, colic, constipation, liver disorders, stomach ulcers
- Urinary disorders
- Adverse sensory organ reactions: decreased vision and hearing, tinnitus
- Other manifestations not noticed before: breathing problems, dermatitis
There is a particularly high risk of complications in those patients who deliberately take a higher dose of Pentalgin.
Features of application
For acute toothache, any Pentalgin should be taken no more than 3 times a day, 1 tablet. Under no circumstances should you take a double dose if suddenly the drug does not work. More than 4 hours should pass between tablets.
If the pain is not severe enough, you can take half the tablet, breaking it along the line. You need to swallow them whole. In the interests of the stomach, it is better to take the medicine with a full glass of water.
If you still have Pentalgin with codeine in your medicine cabinet, which was prescribed several months ago, it is better to consult a doctor about taking it. Despite the fact that previously such tablets were freely available, and patients themselves decided when to take them, codeine also has a number of serious contraindications that the patient may not be aware of.
Pentalgin with codeine is not recommended for children under 16 years of age.
New Pentalgin is not advisable for patients under 12 years of age.
There is no need to delay going to the dentist, because it is inevitable anyway
Any analgesics should not be taken for more than 3 or less than 5 days. Usually by this time the patient has already reached a specialist. But there are also heroes who patiently save themselves with pills and plan to delay the “terrible meeting” until the deadline, when the inflammation has already crossed all boundaries and brings with it a lot of complications.
Attention! Only a doctor can prescribe long-term treatment with Pentalgin in cases where the benefits of the drug outweigh the risks. Moreover, if treatment lasts more than a week, the patient must check the condition of the liver and blood. Within a week of taking Pentalgin with codeine, you may develop a dependence on the drug.
